{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:48:17Z","timestamp":1791949697936,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52371255"],"award-info":[{"award-number":["52371255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Reactivating legacy antibiotics offers a practical route to combat drug\u2010resistant infections, but requires delivery systems that coordinate bacterial engagement with pathogen\u2010triggered drug release. Here, we report DFC, a deferoxamine (DFO)\u2010reprogrammed Fe\u2010carbenicillin (Car) coordination nanoassembly that restores the activity of the legacy \u03b2\u2010lactam antibiotic Car against MRSA. DFC was fabricated via DFO\u2010mediated competitive coordination, transforming homogeneous Fe\u2010Car networks into heterogeneous Car\u2010Fe\u2010DFO structures. Computational modeling and spectroscopic analyses showed stronger Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010DFO affinity than Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010Car binding, DFO\u2010induced redistribution of the Fe\u2010centered ligand environment, and sharply weakened Fe\u2010ligand stability after Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010to\u2010Fe\n                    <jats:sup>2+<\/jats:sup>\n                    conversion. This coordination reprogramming allowed DFC to remain assembled under nonreducing conditions but rapidly disassemble and release Car under reducing conditions or upon exposure to MRSA. DFC enhanced MRSA targeting, biofilm penetration, and intracellular Fe\/Car\u2010associated accumulation, while Fe\u2010valence\u2010triggered destabilization promoted Car release, disrupted iron homeostasis, amplified oxidative stress and lipid peroxidation, and damaged the bacterial envelope. Collectively, these synergistic effects re\u2011established \u03b2\u2010lactam susceptibility, conferred robust antibacterial and anti\u2011biofilm efficacy, and markedly promoted pathogen clearance as well as tissue repair, as evidenced in both infected wound and osteomyelitis models. This study establishes competitive coordination reprogramming as a chemical strategy for coupling bacterial iron metabolism with antibiotic liberation and resistance reversal.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71836","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:29:31Z","timestamp":1791948571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coordination Reprogramming of Fe\u2010Antibiotic Assemblies Enables Valence\u2010Gated \u03b2\u2010Lactam Reactivation"],"prefix":"10.1002","author":[{"given":"Zhengjiang","family":"Xu","sequence":"first","affiliation":[{"name":"Research Center for Human Tissues &amp; Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Human Tissues &amp; Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0767-3496","authenticated-orcid":false,"given":"Ben","family":"Wu","sequence":"additional","affiliation":[{"name":"Research Center for Human Tissues &amp; Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkang","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center for Human Tissues &amp; Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingge","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Putuo Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-3923","authenticated-orcid":false,"given":"Lijing","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Microbiology College of Basic Medical Science Army Medical University  Chongqing China"},{"name":"Department of Emergency Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-7189","authenticated-orcid":false,"given":"Changshun","family":"Ruan","sequence":"additional","affiliation":[{"name":"Research Center for Human Tissues &amp; Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-8572","authenticated-orcid":false,"given":"Haobo","family":"Pan","sequence":"additional","affiliation":[{"name":"Research Center for Human Tissues &amp; Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-1722","authenticated-orcid":false,"given":"Yan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Putuo Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-4391","authenticated-orcid":false,"given":"Shuogui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Department of Emergency and Trauma Changhai Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8235-4472","authenticated-orcid":false,"given":"Guocheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Human Tissues &amp; Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"},{"name":"State Key Laboratory of Biomedical Imaging Science and System Shenzhen Institutes of Advanced Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/apm.12673","article-title":"Antibiotic Treatment of Biofilm Infections","volume":"125","author":"Ciofu O.","year":"2017","journal-title":"Apmis"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/s41551-022-00950-x","article-title":"A Potent Antibiotic\u2010Loaded Bone\u2010Cement Implant Against Staphylococcal Bone Infections","volume":"6","author":"Ghosh S.","year":"2022","journal-title":"Nature Biomedical Engineering"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-019-0061-z","article-title":"Evolving Concepts in Bone Infection: Redefining \u201cBiofilm\u201d, \u201cAcute vs. chronic Osteomyelitis\u201d, \u201cthe Immune Proteome\u201d and \u201cLocal Antibiotic Therapy\u201d","volume":"7","author":"Masters E. 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