{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:52:31Z","timestamp":1791874351023,"version":"4.3.4"},"reference-count":194,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22575143"],"award-info":[{"award-number":["22575143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Infected bone defects are not simply bone defects complicated by bacterial infection; they are dynamic pathological niches in which biofilms, intracellular bacterial persistence, oxidative stress, dysregulated immunity, vascular failure, and pathological bone remodeling are mutually reinforcing. This coupling explains why bacterial killing alone rarely restores functional bone. Metal\u2010polyphenol networks (MPNs), assembled through reversible coordination between metal ions and polyphenols, can translate these pathological stimuli into programmable therapy. Their tunable composition, interfacial adhesion, and pH\/redox\u2010responsive disassembly support a therapeutic transition from early infection control to redox\u2010inflammatory regulation and vascularized bone regeneration. This review presents a disease\u2010oriented framework connecting MPN chemistry and architecture with the evolving microenvironment of infected bone defects. Recent strategies for targeting planktonic and biofilm\u2010associated bacteria, balancing reactive oxygen species generation and scavenging, reshaping osteoimmune signaling, protecting mitochondrial function, coupling angiogenesis with osteogenesis, and rebalancing bone remodeling are critically examined. Emphasis is placed on stage\u2010oriented design, therapeutic trade\u2010offs, and translational gaps. Priorities include eliminating hidden bacterial reservoirs, controlling ion dosing and long\u2010term safety, evaluating functional vascularization and mechanical integration, and standardizing disease models. MPNs are thereby positioned as programmable platforms that coordinate infection resolution with durable bone regeneration.<\/jats:p>","DOI":"10.1002\/adhm.71839","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:39:03Z","timestamp":1791873543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metal\u2010Polyphenol Network\u2010Based Biomaterials for Infected Bone Defects: Microenvironment Regulation and Stage\u2010Oriented Regenerative Strategies"],"prefix":"10.1002","author":[{"given":"Yuanhong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthodontics Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological Hospital &amp; School of Stomatology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6443-0601","authenticated-orcid":false,"given":"Ziyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oral Sciences Faculty of Dentistry University of Otago  Dunedin New Zealand"},{"name":"State Key Laboratory of Oral Diseases &amp; National Center For Stomatology &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center For Stomatology &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center For Stomatology &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyou","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-1868","authenticated-orcid":false,"given":"Jiajia","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological Hospital &amp; School of Stomatology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-7512","authenticated-orcid":false,"given":"Yijun","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(23)00503\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4MH01124D"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110686"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.058"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(03)00292\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3389\/fmicb.2019.01626","article-title":"Antibiotic\u2010Loaded Polymethylmethacrylate Beads and Spacers in Treatment of Orthopedic Infections and the Role of Biofilm Formation","volume":"10","author":"Vugt T. A. G.","year":"2019","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214326"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202202684"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237265"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003210\u20107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2026.214869"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c01042"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c14604"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104536"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135118"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR01892A"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01940"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010022\u201000686\u20100"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914\u2010019\u201000548\u20104"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuae002"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2026.117411"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010022\u201000692\u20102"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409683"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309230"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR01884B"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6c00362"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020317"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010023\u201003476\u20106"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000765\u20103"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109235"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.111540"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.174132"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.124139"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010025\u201000471\u20108"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13027"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00085"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701574"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010025\u201000793\u20109"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S507269"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117389"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062851"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00652.2023"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010024\u201001115\u20107"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101348"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.06.050"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.11.057"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232\u2010023\u201000279\u20101"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.110149"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.172641"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.03.043"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4171"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3668"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo1072"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjtee.2021.07.006"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123423"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100858"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100660"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201029808\u20103"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101664"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216743"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202403883"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00383F"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102267"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.01.014"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.11.038"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c19621"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b09237"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123323"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30061218"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b19865"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25169100"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770\u2010026\u201000804\u20106"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202410496"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201311136"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2025.102822"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering12101021"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534\u2010023\u201000565\u2010y"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.174500"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216205"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102638"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaf068"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00368"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303529"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010018\u20100149\u20103"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaf014"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.10.009"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123718"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13515"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2022.121831"},{"key":"e_1_2_10_91_1","doi-asserted-by":"crossref","unstructured":"M. S.Menyo C. J.Hawker andJ. H.Waite \u201cRate\u2010Dependent Stiffness and Recovery in Interpenetrating Network Hydrogels Through Sacrificial Metal Coordination Bonds \u201dACS Macro Letters4(2015):1200\u20131204 https:\/\/doi.org\/10.1021\/acsmacrolett.5b00664. PMID: 27818845.","DOI":"10.1021\/acsmacrolett.5b00664"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807804"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111851"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC04883F"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02279"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201403343"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202205489"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.4c01724"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202521074"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c03227"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b01067"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307680"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145608"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400513"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00273J"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423799"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010026\u201000438\u20103"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c01093"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.01.059"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1039\/D6BM00475J"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203063"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202109011"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB02649G"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2025.102850"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202526857"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat7520"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2025.07.021"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201005553\u20109"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423654"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010021\u201001798\u20104"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5c01515"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.124313"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2024.02.054"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.4c02118"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230087"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.58711"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101354"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.111401"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08165"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123417"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2019.102019"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.6c00108"},{"key":"e_1_2_10_133_1","first-page":"118","article-title":"Copper Tannic Acid Coordination Nanosheet as a Potent in\u2010situ Antibiotic Sustained\u2010release Carrier for Chronic Osteomyelitis","volume":"36","author":"Zhang Y.","year":"2025","journal-title":"Journal of Materials Science: Materials in Medicine"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123916"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c03028"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202503470"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302485"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201083982\u20104"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202513698"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101907"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103941"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.171049"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c05266"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301924"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202412441"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA00481G"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01940"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202518003"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202510869"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123843"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2026.117126"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010022\u201000456\u2010z"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309491"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.08.018"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c21265"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c05859"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u201000488\u20106"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c07091"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.933550"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765\u2010024\u201000487\u20105"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaf032"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf072"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202403681"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2024.102393"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010023\u201003631\u20101"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144167"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114335"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216746"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102213"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB02717A"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123696"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100215\u20107"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202411189"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404804"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111360"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2025.138355"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300303"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302690"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536\u2010023\u201000288\u20101"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202518807"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100793"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.066"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142893"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB00631G"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536\u2010023\u201000305\u20103"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101777"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202509997"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.12.002"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.124200"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.06.002"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0968"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1080\/09506608.2016.1266744"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010022\u201000899\u20106"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040459\u20108"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71839","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:39:05Z","timestamp":1791873545000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":194,"alternative-id":["10.1002\/adhm.71839"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71839","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"2026-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71839"}}