{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:49:20Z","timestamp":1791866960459,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22577169"],"award-info":[{"award-number":["22577169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024B1515040028"],"award-info":[{"award-number":["2024B1515040028"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The hypoxic and immunosuppressive tumor microenvironment limits photodynamic therapy (PDT) and antitumor immunity. To address this, we construct a hypoxia\u2010adaptive nanoplatform\n                    <jats:bold>PG@Mn\u2010ZIF8<\/jats:bold>\n                    by co\u2010encapsulating a J\u2010aggregating platinum photosensitizer\n                    <jats:bold>Pt\u20103T<\/jats:bold>\n                    and the nitric oxide (NO) donor S\u2010nitrosoglutathione (GSNO) within Mn\n                    <jats:sup>2+<\/jats:sup>\n                    \/Zn\n                    <jats:sup>2+<\/jats:sup>\n                    doped ZIF\u20108. This nanoplatform can decompose endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    to O\n                    <jats:sub>2<\/jats:sub>\n                    via Pt aggregate\u2010mediated catalase (CAT)\u2010mimetic activity, alleviating hypoxia before light irradiation. Upon illumination,\n                    <jats:bold>Pt\u20103T<\/jats:bold>\n                    generates a robust Type I\/II reactive oxygen species (ROS) storm, which triggers rapid NO release from GSNO, and further convert ROS and NO into highly cytotoxic peroxynitrite (ONOO\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    ), thereby amplifying an ROS\/RNS storm within the confined MOF space. This co storm disrupts redox homeostasis to induce both necroptosis and ferroptosis alongside immunogenic cell death (ICD). Moreover, the released Mn\n                    <jats:sup>2+<\/jats:sup>\n                    and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    upon MOF degradation synergistically potentiate the cyclic GMP\u2010AMP (cGAMP) synthase (cGAS)\u2013stimulator of interferon genes (STING) pathway. Consequently, the spatiotemporal \u201cO\n                    <jats:sub>2<\/jats:sub>\n                    \u2013ROS\/RNS\u2013metal ions\u201d cascade enables the nanoplatform to trigger multimodal cell death and ignite cGAS\u2010STING\u2010driven innate and adaptive immunity, eradicating solid tumors, establishing long\u2010term immune memory, and reversing the \u201ccold\u201d tumor phenotype.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71845","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:39:27Z","timestamp":1791866367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoxia\u2010Adaptive Confined Cascade Nanoplatform Unleashing ROS\/RNS Storm and Metal Ions to Orchestrate Necroptosis, Ferroptosis, and cGAS\u2010STING Immunity"],"prefix":"10.1002","author":[{"given":"Zhi\u2010Yuan","family":"Li","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ying","family":"Han","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8359-9626","authenticated-orcid":false,"given":"Qing\u2010Hua","family":"Shen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8228-830X","authenticated-orcid":false,"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long\u2010Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-8367","authenticated-orcid":false,"given":"Cai\u2010Ping","family":"Tan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat\u2010Sen University  Guangzhou P. R. China"},{"name":"Guangdong Basic Research Center of Excellence for Functional Molecular Engineering  Guangzhou P. R. China"},{"name":"State Key Laboratory of Anti\u2010Infective Drug Discovery and Development School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.12.020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010025\u201000705\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202525238"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300089"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215482"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.163962"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.115084"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121433"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202418894"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c03172"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307143"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202501271"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121854"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.123990"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.163245"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.174968"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202206554"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147437"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202503206"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202314536"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.170750"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.217320"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00597"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202416122"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312488"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202210988"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c07413"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00352"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843\u2010024\u20102976\u20108"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202521718"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01671"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c21676"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.174217"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202517286"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c01678"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c18781"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c10714"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c21748"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c21676"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202521146"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6c00090"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202502154"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202508310"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja203920w"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5c03296"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.124005"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c03847"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc44962a"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101515"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:39:36Z","timestamp":1791866376000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":49,"alternative-id":["10.1002\/adhm.71845"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71845","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"2026-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71845"}}