{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:50:10Z","timestamp":1792403410214,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS\u20102023\u201000265159"],"award-info":[{"award-number":["RS\u20102023\u201000265159"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS\u20102023\u201000274152"],"award-info":[{"award-number":["RS\u20102023\u201000274152"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In 2022, a global Mpox outbreak occurred, and the World Health Organization (WHO) declared it a Public Health Emergency of International Concern (PHEIC). Although the outbreak was quickly constrained, new cases of infection associated with mutated virions continue to be documented worldwide. In recent global health crises, there is an urgent need to develop rapid, cost\u2010effective diagnostic assays. While nucleic acid assays (e.g., PCR and CRISPR\u2010based methods) represent the current gold standard for Mpox virus (MPXV) detection, point\u2010of\u2010care (POC) assays for Mpox remain limited. Here, we developed a molecularly imprinted polymer (MIP)\u2010based MPXV sensor targeting A29L, a surface protein involved in host cell binding. The MIP sensor exhibits a remarkable detection limit of 7.7 pg\/mL (0.54 pM). Moreover, we demonstrated that the MIP sensor detected A29L in artificial interstitial fluid (AIF) with a detection limit of 12.4 pg\/mL (0.86 pM), supporting sensitive detection in a lesion\u2010relevant model matrix. The MIP sensor preferentially responded to A29L over MPXV B6R, vaccinia virus A27L, and biointerferents and retained its response after 30 days. The results indicate that the MIP\u2010based MPXV sensor has strong potential for clinical Mpox detection and could serve as a valuable diagnostic platform in future pandemics.<\/jats:p>","DOI":"10.1002\/adhm.71847","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:36:26Z","timestamp":1792402586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pandemic\u2010Responsive Molecularly Imprinted Polymer\u2010Based Electrochemical Sensor for Mpox Detection"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-5866","authenticated-orcid":false,"given":"Youngjun","family":"Seo","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"},{"name":"Interdisciplinary Program in Precision Public Health Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3826-8208","authenticated-orcid":false,"given":"Jaeheung","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"},{"name":"Interdisciplinary Program in Precision Public Health Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Won","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Incheon National University  Incheon Republic of Korea"},{"name":"Integrated Major in Bio\u2010manufacturing AX Incheon National University  Incheon Republic of Korea"},{"name":"Research Center for Bio Materials and Process Development Incheon National University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-927X","authenticated-orcid":false,"given":"Hyo Gi","family":"Jung","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"},{"name":"Center For Systems Biology Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-7114","authenticated-orcid":false,"given":"Dongsung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Sciences University of California  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghoon","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"},{"name":"Interdisciplinary Program in Precision Public Health Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0196-7910","authenticated-orcid":false,"given":"Hongrae","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"},{"name":"Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"},{"name":"Department of Bioengineering Incheon National University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Bang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"},{"name":"Department of Bioengineering Incheon National University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6908-7962","authenticated-orcid":false,"given":"Hyunji","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul Republic of Korea"},{"name":"Interdisciplinary Program in Precision Public Health Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-6060","authenticated-orcid":false,"given":"Jeong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"KU\u2010KIST Graduate School of Converging Science and Technology Korea University  Seoul Republic of Korea"},{"name":"Department of Integrative Energy Engineering College of Engineering Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8716-1736","authenticated-orcid":false,"given":"Dongtak","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Incheon National University  Incheon Republic of Korea"},{"name":"Integrated Major in Bio\u2010manufacturing AX Incheon National University  Incheon Republic of Korea"},{"name":"Research Center for Bio Materials and Process Development Incheon National University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-2074","authenticated-orcid":false,"given":"Kyo Seon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Precision Medicine Graduate School Kyung Hee University  Seoul Republic of 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