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We designed a bimetallic CoNi\u2010based metal\u2013organic framework (CoNi\u2010MOF) with enhanced multienzyme\u2010like activities: oxidase\u2010like (OXD\u2010like), peroxidase\u2010like (POD\u2010like), and catalase\u2010like (CAT\u2010like) activities. The superior performance arises from the synergy between Co and Ni, which shifts the d\u2010band center of Co closer to the Fermi level than those in Co\u2010MOF and Ni\u2010MOF. This electronic structure enhancement facilitates substrate adsorption and lowers reaction energy barriers, accounting for the strong enzyme\u2010like activities of CoNi\u2010MOF. At acidic infection sites, OXD\u2010like and POD\u2010like activities are activated to generate antibacterial ROS, effectively eliminating drug\u2010resistant bacteria. As bacterial clearance occurs and the wound returns to neutrality, CoNi\u2010MOF exhibits CAT\u2010like activity and radical scavenging capabilities to eliminate excess ROS, thereby restoring oxidative balance and mitigating inflammation. Moreover, CoNi\u2010MOF promotes macrophage polarization from the pro\u2010inflammatory M1 phenotype toward the pro\u2010regenerative M2 phenotype. This pH\u2010responsive enzymatic activity offers a self\u2010adaptive therapeutic strategy, as validated by in vivo studies showing accelerated wound healing. This self\u2010adaptive nanozyme platform integrates antibacterial, antioxidant, and immunomodulatory functions, offering a promising antibiotic\u2010free treatment for drug\u2010resistant bacterial wound infections.<\/jats:p>","DOI":"10.1002\/adhm.71851","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:48:24Z","timestamp":1792054104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Self\u2010Adaptive CoNi\u2010Based Metal\u2013Organic Framework for Autonomous Antibacterial Efficacy and Anti\u2010Inflammatory Resolution in Accelerated Wound Healing"],"prefix":"10.1002","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei P.R. 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