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Here, a dynamic bispecific aptamer within triglycerol monostearate (TGMS) nanoparticles hydrogel termed REMEDY (receptor dimerization\u2010engineering directed hydrogel) was developed to modulate cellular behavior in an on\u2010demand manner. The REMEDY was fabricated by dual rolling circle amplification to deliver bispecific receptor tyrosine kinase (RTK) aptamers, thereby effectively promoting cell receptor dimerization. The TGMS nanoparticles loaded with restriction endonuclease\n                    <jats:italic>Eco<\/jats:italic>\n                    R I controllably released bispecific RTK aptamers through\n                    <jats:italic>Eco<\/jats:italic>\n                    R I\u2010triggered hydrogel disintegration in response to inflammation. The REMEDY successfully manipulated cell\u2010surface MET receptor dimerization and activated MAPK\/ERK and PI3K\/AKT signaling pathways. RNA sequencing analysis further revealed that activated pathways upregulated the expression of\n                    <jats:italic>Krt1, Vegfb<\/jats:italic>\n                    , while downregulating\n                    <jats:italic>Il1b<\/jats:italic>\n                    , which were closely associated with target cells proliferation, migration, and phenotypic polarization. A murine wound model was subsequently constructed to validate the practical therapeutic efficacy. Results demonstrated that REMEDY significantly enhanced wound healing rates by 26.35% in acute wounds and 58.70% in chronic wounds. The REMEDY provides a paradigm for converting nanoscale molecular operation to the microscale behaviors regulation and paves the pathway for advancing precise cell therapy in regenerative medicine.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71852","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:34:33Z","timestamp":1792038873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Receptor Dimerization\u2010Engineering Hydrogel to On\u2010Demand Regulate Cellular Behaviors"],"prefix":"10.1002","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"School of Laboratory Medicine Chengdu Medical College  Chengdu Sichuan 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