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Respiratory infection adds a moving interface, as epithelial secretion, surfactant composition, plasma leakage, and neutrophil\u2010derived material vary across airway compartments and over time. Pulmonary and disease\u2010corona studies already establish that host environments influence nanoparticle identity. The next question is how this knowledge should change formulation selection and dosing for infected lungs. We propose an infection\u2010phase framework based on measured, overlapping airway environments. It connects the post\u2010aerosol particle to its surface\u2010associated biomolecules, distinguishes this interface from aggregation and bulk mucus effects, and links analytical measurements to functional delivery. A staged research program begins with one compartment and two contrasting environments, then adds controlled particle\u2010transfer experiments, candidate\u2010component perturbation, and donor\u2010level validation. Lipid nanoparticles, polymeric carriers, and nanozymes require different functional endpoints within this shared framework. The immediate translational output is a biorelevant performance stress test that identifies robust or environment\u2010selective formulations and guides the next experiment.<\/jats:p>","DOI":"10.1002\/adhm.71853","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:14:31Z","timestamp":1791962071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infection\u2010Phase Biomolecular Coronas in Inhaled Nanomedicine"],"prefix":"10.1002","author":[{"given":"Zhenchao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking University Third Hospital  Beijing China"},{"name":"Center for Infectious Diseases Peking University Third Hospital  Beijing China"},{"name":"National Key Laboratory of Vascular Homeostasis and Remodeling Peking University  Beijing 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