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Here, a light\u2010curable, swelling\u2010resistant Janus hydrogel patch is developed as a pseudomembrane\u2010inspired protective barrier. The tissue\u2010facing adhesive layer incorporates 2\u2010phenoxyethyl acrylate (PEA), \u03b1\u2010lipoic acid (LA), and acryloyl NHS esters, achieving a wet tissue shear adhesion strength of 142\u00a0kPa. PEA is proposed to facilitate wet tissue contact, LA participates in the polymer network, and NHS esters provide covalent anchoring. The hydrophobic network constrains water uptake, limiting further wet\u2010state mass gain to approximately 3% and volumetric expansion to approximately 10% after 7 days. Dynamic fluid circulation tests further demonstrate the patch's durability under simulated oral conditions. The outward\u2010facing zwitterionic layer mimics the mucosal barrier, providing protection against mechanical abrasion and chemical irritation. In a rat model, the patch maintains structural integrity for 3 days, accelerates re\u2010epithelialization, and modulates the inflammatory microenvironment. This Janus design provides sustained protection for injured mucosal surfaces and facilitates oral ulcer healing.<\/jats:p>","DOI":"10.1002\/adhm.71855","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:20:42Z","timestamp":1792077642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Pseudomembrane\u2010Inspired Janus Hydrogel Patch With Robust Wet Adhesion and Swelling\u2010Resistant Capabilities for Accelerated Oral Ulcer Healing"],"prefix":"10.1002","author":[{"given":"Zihang","family":"Fei","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of New Generation Semiconductor Technology and System School of Integrated Circuits Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Mechatronics Engineering The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Dai","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of New Generation Semiconductor Technology and System School of Integrated Circuits Shandong University  Jinan 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