{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:49:26Z","timestamp":1791971366663,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572678"],"award-info":[{"award-number":["82572678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Biofilm\u2010associated infections caused by Gram\u2010positive pathogens remain highly resistant to conventional antibiotic therapy due to restricted drug penetration and persistent inflammatory microenvironments. Inspired by the catalytic versatility and biocompatibility of cobalt, a series of cobalt\u2010based diatomic nanozymes were rationally engineered for catalytic antibacterial therapy. Among them, cobalt\/copper diatomic nanozymes (Co\/Cu\u2010DAzymes) exhibited the most pronounced antibacterial and antibiofilm activities. Structural characterization supports the presence of highly dispersed Co and Cu coordination sites, while DFT calculations based on an idealized adjacent Co\u2013Cu model suggest that heteronuclear electronic interactions may facilitate H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    activation and ROS generation.Co\/Cu\u2010DAzymes achieve more than 95% antibacterial efficiency against both Group A\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    (GAS) and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , while inhibiting biofilm formation by over 80%, with negligible cytotoxicity in vitro and in vivo. In a murine GAS\u2010infected wound model, treatment with Co\/Cu\u2010DAzymes combined with low\u2010dose H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    significantly accelerated wound closure and was associated with histological features of more advanced tissue repair. These findings highlight the potential contribution of heteronuclear electronic interactions to catalytic H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    activation and provide a plausible design basis for developing antibacterial dual\u2010metal nanozymes.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71857","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:02:41Z","timestamp":1791968561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electronic Interactions in Co\/Cu Biotomic Nanozymes for Catalytic Eradication of Gram\u2010Positive Bacterial Biofilms"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7174-2447","authenticated-orcid":false,"given":"Zixuan","family":"Tang","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Sui","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-5468","authenticated-orcid":false,"given":"Han","family":"Lin","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Ceramics Chinese Academy of Sciences Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease Chinese Academy of Medical Sciences  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0710-6721","authenticated-orcid":false,"given":"Feiyun","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Harbin Medical University  Harbin China"},{"name":"Heilongjiang Provincial Key Laboratory of Human Microphysiological Systemsand Organoids\u2010On\u2010A\u2010Chip (Harbin Medical University) and Heilongjiang Provincial Joint Laboratory of Basic Medicine and Multiple Organ System Diseases (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2024.2412745"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010023\u201000865\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanwpc.2022.100507","article-title":"Risk Factors for Group A Streptococcal Pharyngitis and Skin Infections: A Case Control Study","volume":"26","author":"Bennett J.","year":"2022","journal-title":"Lancet Regional Health\u2013Western Pacific"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104609"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.84"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010024\u201002601\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010020\u20100420\u20101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3390\/genes15091166","article-title":"Molecular Targets in Streptococcus pyogenes for the Development of Anti\u2010Virulence Agents","volume":"15","author":"Cho K. 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