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The advantages, including the favorable tumor\u2010targeting affinity (RGD peptide), high renal clearance efficiency, and tumor\u2010specific fluorescence activation, are achieved by rationally engineering the molecular architecture. Benefiting from these characteristics, the\n                    <jats:bold>\n                      NO\n                      <jats:sub>2<\/jats:sub>\n                      \u2010RGD\u2010Gd\n                    <\/jats:bold>\n                    effectively bridges the boundary between diagnosis and therapy, achieving outstanding combinatorial performance in in vivo applications. It allows early and precise diagnosis through urinary biomarkers, provides anatomical\u2010pathological and molecular imaging information of tumor lesions via fluorescence\u2010MR dual\u2010modal imaging, and delineates tumor boundaries for accurate surgical navigation relying on tumor\u2010targeted activatable fluorescence imaging signals. Furthermore, all these processes can be realized simply via intravenous injection, offering a more efficient and feasible strategy for integrated diagnostic and therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71862","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:35:26Z","timestamp":1792157726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enzyme\u2010Activatable Probe for Tumor Bimodal Imaging, Intraoperative Navigation, and Urinalysis"],"prefix":"10.1002","author":[{"given":"Meilin","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Intelligent Nanomedicine and Tracing College of Chemistry Beijing University of Chemical Technology Beijing P. R. 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