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Although decellularized uterine extracellular matrix (dUECM) holds promise for uterine reconstruction, its clinical translation is limited by rapid degradation and poor angiogenic capacity. Herein, a dual\u2010component system was developed by combining oligomeric proanthocyanidin (OPC)\u2010crosslinked dUECM with an injectable VEGF\u2010loaded nanocomposite hydrogel. The OPC\u2010dUECM scaffold (1 mg\/mL OPC solution) restored native\u2010like tensile strength, reduced collagenase\u2010induced degradation to 52%, and facilitated cellular infiltration. The VEGF\u2010EPL\u2010HP nanocomposite hydrogel was fabricated by encapsulating VEGF (350 ng\/mL) in \u03b5\u2010polylysine\/heparin\u2010poloxamer (EPL\u2010HP) nanoparticles dispersed within a thermosensitive hydrogel. The hydrogel exhibited a gelation temperature of 23.2\u00b0C, provided sustained VEGF release over 7 days, and showed negligible hemolytic toxicity. In vitro, this hydrogel significantly enhanced the migration and tube formation of human umbilical vein endothelial cells. At 90 days post\u2010surgery in a rat uterine defect model, the combined OPC\u2010dUECM + VEGF\u2010EPL\u2010HP group achieved full endometrial and myometrial regeneration, accompanied by elevated microvessel density, attenuated inflammation, and negligible fibrotic lesions. Collectively, this study validated a synergistic scaffold\u2010hydrogel platform enabling concurrent structural reconstruction and vascularization of the injured uterus, offering a clinically translatable strategy for AUFI patients.<\/jats:p>","DOI":"10.1002\/adhm.71863","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:34:36Z","timestamp":1792474476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scaffold\u2010Hydrogel Synergy with OPC\u2010Crosslinked dUECM and VEGF\u2010Nanocomposite Hydrogel Achieves Dual \u201cStructural\u2010Vascular\u201d Regeneration in Rats"],"prefix":"10.1002","author":[{"given":"Xinji","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou Zhejiang Province People's Republic of China"},{"name":"Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic 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