{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:40:58Z","timestamp":1792377658100,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51377163"],"award-info":[{"award-number":["51377163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Severe endometrial injury is a leading cause of female infertility, driven by the convergence of inadequate vascularization, persistent inflammation, infection, and excessive fibrosis. Existing therapies address these pathologies in isolation, falling short of the coordinated remodeling essential for functional regeneration. Here, we report an injectable, thermally responsive composite hydrogel that embeds copper\u2010based metal\u2013organic framework (HKUST\u20101) nanoparticles within a porcine acellular dermal matrix (PADM) network, coupling biomimetic extracellular matrix support with sustained Cu\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    delivery. In vitro, the hydrogel promotes endothelial migration and tubular network formation, shifts macrophage polarization toward the reparative M2 phenotype, and exhibits broad\u2010spectrum bactericidal activity. In a rat endometrial injury model, it increases gland density and CD31\n                    <jats:sup>+<\/jats:sup>\n                    neovascularization while suppressing fibrotic collagen deposition. Crucially, it restores hormonal responsiveness by upregulating estrogen and progesterone receptor expression. These coordinated improvements translate into meaningful fertility restoration, with implanted embryos increasing from 8 \u00b1 2 to 14 \u00b1 1. Transcriptomic profiling indicates coordinated changes in extracellular matrix remodeling and ion transport programs. The PADM@HKUST\u20101 hydrogel demonstrates that integrating biomimetic scaffolding with sustained bioactive ion delivery achieves comprehensive uterine microenvironment remodeling, offering a translatable approach for clinical management of severe endometrial injury.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71864","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:21:04Z","timestamp":1792376464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Copper Metal\u2013Organic Framework\u2010Embedded Decellularized Matrix Hydrogel Remodels the Uterine Microenvironment for Endometrial Regeneration and Fertility Restoration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2163-301X","authenticated-orcid":false,"given":"Xingyu","family":"Ma","sequence":"first","affiliation":[{"name":"School of Medicine Northwest University  Xi'an People's Republic of 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Western China Provincial Key Laboratory of Biotechnology Ministry of Education College of Life Sciences Northwest University  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8457-5991","authenticated-orcid":false,"given":"Meimei","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Medicine Northwest University  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Xijing Hospital Air Force Military Medical University  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-0003","authenticated-orcid":false,"given":"Xiaojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine Northwest University  Xi'an People's Republic of 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