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To address this, alendronate\u2010conjugated citrate\u2010based composite microscaffolds, consisting of an alendronate (ALN) conjugated poly (octamethylene citrate) prepolymer mixed with hydroxyapatite (HA) (APOC\u2010HA), was developed followed by thermal post\u2010polymerization. Benefiting from the novel composite cylinder fabrication process using powder compression method in a custom\u2010designed three\u2010part split mold, and the chelation interaction between ALN and HA, the compression strength of the nonporous composite cylinders exceeded 250\u00a0MPa. Upon implantation, ALN conjugated on the polymer chains effectively inhibits osteoclast activity as the material degrades. Simultaneously, the sustained release of citrate, a key metabolic regulator, enhances the energy metabolism of bone marrow mesenchymal stem cells (BMSCs) via participating tricarboxylic acid (TCA) cycle, promoting osteogenic differentiation and mineralization. The crosslinked APOC\u2010HA scaffold provides robust mechanical support and excellent biocompatibility while improving bone homeostasis. Consequently, this dual\u2010functional biomaterial offers favorable conditions for regeneration in osteoporotic defects, representing a promising strategy for future clinical applications.<\/jats:p>","DOI":"10.1002\/adhm.71874","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:31:43Z","timestamp":1792654303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alendronate\u2010Conjugated Citrate\u2010Based Composite Microscaffolds Promote Osteoporotic Bone Regeneration via Activating Osteogenesis and Suppressing Osteoclastogenesis"],"prefix":"10.1002","author":[{"given":"Shiyuan","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology School of Basic Medical Sciences Southern Medical University  Guangzhou P. R. 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