{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:36:46Z","timestamp":1792831006467,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>High\u2010pressure drug\u2010coated balloon (HP@DCB) angioplasty enhances vascular drug delivery by overcoming the limitations of passive diffusion\u2010based conventional noncompliant DCB (NC@DCB) systems. We developed a dual\u2010layer HP balloon catheter composed of an outer Nylon 12 layer and an inner Pebax 7233 layer, and evaluated its feasibility and therapeutic efficacy as a paclitaxel (PTX)\u2010coated platform. Shellac\u2010based PTX coating was uniformly applied to HP@DCB and NC@DCB, and coating thickness, drug amount, release behavior, and mechanical properties were compared. Pressure\u2010assisted drug penetration was assessed in a vascular\u2010mimicking agarose gel phantom using fluorescent PTX and confocal microscopy. In vivo efficacy was evaluated in a balloon injury\u2010induced rabbit iliac artery stenosis model using angiography, optical coherence tomography (OCT), histology, immunohistochemistry, and immunofluorescence examinations. Drug amount, coating thickness, and sustained drug release did not differ between groups. The mechanical robustness in HP@DCB was significantly greater than that in NC@DCB. HP@DCB produced significantly greater penetration depth and fluorescence\u2010positive area, indicating enhanced pressure\u2010assisted drug transfer. HP@DCB resulted in superior luminal patency, reduced neointimal hyperplasia, and favorable biological responses compared with that in NC@DCB and the sham control. These findings support DCB use based on a dual\u2010layered HP balloon platform as a promising next\u2010generation strategy for stenotic vascular lesion treatment.<\/jats:p>","DOI":"10.1002\/adhm.71886","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:41:10Z","timestamp":1792827670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pressure\u2010Assisted Drug Delivery Using High\u2010Pressure Balloon Platform Improves Vascular Drug Penetration and Anti\u2010Restenotic Effects"],"prefix":"10.1002","author":[{"given":"Seung Jin","family":"Eo","sequence":"first","affiliation":[{"name":"Department of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yun","family":"Lim","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3021-1151","authenticated-orcid":false,"given":"Dong\u2010Sung","family":"Won","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-2339","authenticated-orcid":false,"given":"Yubeen","family":"Park","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3893-8051","authenticated-orcid":false,"given":"Hyemin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1587-5673","authenticated-orcid":false,"given":"Jun\u2010Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"IMT Inc.  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