{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:52:57Z","timestamp":1763016777287},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T00:00:00Z","timestamp":1183334400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annali di Chimica"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The construction and general performance of novel potentiometric membrane ion selective electrodes for determination of papaverine hydrochloride has been described. They are based on the formation of the ion association complexes of papaverine (PA) with tetraphenylborate (TPB)(I) or tetrathiocyanate (TTC)(II) counter anions as electro\u2010active material dispersed in a PVC matrix. The electrodes show fast, stable, near Nernstian response for 1\u00d710<jats:sup>\u20102<\/jats:sup> to 6\u00d710<jats:sup>\u20105<\/jats:sup> M and 1\u00d710<jats:sup>\u20102<\/jats:sup> to 1\u00d710<jats:sup>\u20105<\/jats:sup> M for PA\u2010TPB and PA\u2010TTC respectively at 25 \u00b0C over the pH range of 3\u20105.0 with a cationic slope of \u223c 56.5\u00b10.5 mV\/decade for both sensors respectively. The lower detection limit is 4\u00d710<jats:sup>\u20105<\/jats:sup> and 8\u00d710<jats:sup>\u20106<\/jats:sup> M for PA\u2010 I and PA\u2010II respectively with fast response time ranging from 20\u201045 sec. Selectivity coefficients for PA relative to a number of interfering substances were investigated. There is a negligible interference from the studied cations, anions, and pharmaceutical excipients. The determination of 4.0\u20103000.0 \u03bcg\/ml of PA in aqueous solutions shows an average recovery of 99.1 % and a mean relative standard deviation of 1.4 at 100 \u03bcg\/ml. The direct determination of PA in some formulations (Vasorin injection) gave results that compare favorably with those obtained using the British Pharmacopoeia method. Potentiometric titration of PA with sodium tetraphenylborate and potassium thiocyanate as titrants utilizing the papaverine electrode as an end point indicator electrode has been carried out.<\/jats:p>","DOI":"10.1002\/adic.200790060","type":"journal-article","created":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T10:23:58Z","timestamp":1183371838000},"page":"771-780","source":"Crossref","is-referenced-by-count":4,"title":["Papaverine PVC Membrane Ion\u2010Selective Electrodes Based on its Ion\u2010Exchangers with Tetraphenylborate and Tetrathiocyanate Anions"],"prefix":"10.1002","volume":"97","author":[{"given":"Mohammed Noor\u2010Eldeen","family":"Abbas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal Abdel\u2010Hafiz","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"483","volume-title":"British Pharmacopoeia","year":"1994"},{"key":"e_1_2_1_3_2","volume-title":"The Pharmacological Basis Of Therapeutics","author":"Gilman A.G.","year":"1980"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02193767"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00607-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(94)90028-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/ja9930801117"},{"key":"e_1_2_1_8_2","first-page":"75","volume":"34","author":"Pohloudek\u2010Fabini R.","year":"1979","journal-title":"Pharmazie"},{"key":"e_1_2_1_9_2","first-page":"67","volume":"33","author":"Mishutina M.V.","year":"1984","journal-title":"Farmatsiya"},{"key":"e_1_2_1_10_2","first-page":"1471","volume":"13","author":"Bjornsdottir I.","year":"1995","journal-title":"J. Pharm. Biomed. Anal."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02575286"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(87)80058-4"},{"key":"e_1_2_1_13_2","first-page":"322","volume":"122","author":"Maurich V.","year":"1983","journal-title":"Boll. Chim. Farm."},{"key":"e_1_2_1_14_2","first-page":"105","volume":"45","author":"Magnuszewska B.","year":"2000","journal-title":"Chemica Analityczna"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.41.1123"},{"key":"e_1_2_1_16_2","volume-title":"Pharmaceutical Applications Of Membrane Sensors","author":"Cosofret V.V.","year":"1992"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2005.07.061"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2005.03.040"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(02)00663-5"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408349308048818"},{"key":"e_1_2_1_21_2","first-page":"1079","volume":"113","author":"Hassan S.S.M.","year":"1988","journal-title":"Analyst"},{"key":"e_1_2_1_22_2","first-page":"20","volume":"22","author":"Davies J.E.W.","year":"1973","journal-title":"Lab. Pract."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac199466122527"},{"key":"e_1_2_1_24_2","first-page":"368","volume-title":"Analytical Profiles Of Drug Substances","author":"Flory K.","year":"1988"},{"key":"e_1_2_1_25_2","volume-title":"Organic Analysis Using Ion Selective Electrodes","author":"Ma T.S.","year":"1982"}],"container-title":["Annali di Chimica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadic.200790060","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adic.200790060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:37:43Z","timestamp":1699961863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adic.200790060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1002\/adic.200790060"],"URL":"https:\/\/doi.org\/10.1002\/adic.200790060","archive":["Portico"],"relation":{},"ISSN":["0003-4592","1612-8877"],"issn-type":[{"value":"0003-4592","type":"print"},{"value":"1612-8877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}