{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:11:51Z","timestamp":1788509511468,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600803"],"award-info":[{"award-number":["31600803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21273051"],"award-info":[{"award-number":["21273051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470049"],"award-info":[{"award-number":["31470049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDA09030306"],"award-info":[{"award-number":["XDA09030306"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["2162044"],"award-info":[{"award-number":["2162044"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Alzheimer's disease (AD) is the most common form of dementia characterized by progressive cognitive decline. Current diagnosis of AD is based on symptoms, neuropsychological tests, and neuroimaging, and is usually evident years after the pathological process. Early assessment at the preclinical or prodromal stage is in a great demand since treatment after the onset can hardly stop or reverse the disease progress. However, early diagnosis of AD is challenging due to the lack of reliable noninvasive approaches. Here, an antibody\u2010mimetic self\u2010assembling peptoid nanosheet containing surface\u2010exposed A\u03b242\u2010recognizing loops is constructed, and a label\u2010free sensor for the detection of AD serum is developed. The loop\u2010displaying peptoid nanosheet is demonstrated to have high affinity to serum A\u03b242, and to be able to identify AD sera with high sensitivity. The dense distribution of molecular recognition loops on the robust peptoid nanosheet scaffold not only mimics the architecture of antibodies, but also reduces the nonspecific binding in detecting multicomponent samples. This antibody\u2010mimetic 2D material holds great potential toward the blood\u2010based diagnosis of AD, and meanwhile provides novel insights into the antibody alternative engineering and the universal application in biological and chemical sensors.<\/jats:p>","DOI":"10.1002\/adma.201700057","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T08:56:41Z","timestamp":1497257801000},"source":"Crossref","is-referenced-by-count":71,"title":["Antibody\u2010Mimetic Peptoid Nanosheet for Label\u2010Free Serum\u2010Based Diagnosis of Alzheimer's Disease"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-6093","authenticated-orcid":false,"given":"Ling","family":"Zhu","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Zhao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing 400016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine  Baltimore MD 21205 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Peng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayi","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlian","family":"Yang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"},{"name":"Sino\u2010Danish Colloge University of Chinese Academy of Sciences  Beijing 100049 China"},{"name":"Yangtze River Delta Academy of Nanotechnology and Industry Development Research Zhejiang Province  Jiaxing 314000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00502-7"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp062"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02621"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3281a47744"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986707779313471"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90008-A"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt162"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.01.065"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.08.008"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101860"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.06.175"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac501348n"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(94)90001-9"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2003.10.012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1352(200007\/08)13:4<167::AID-JMR502>3.0.CO;2-9"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1142"},{"key":"e_1_2_5_14_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.04.627"},{"key":"e_1_2_5_14_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2012.07.006"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03540504"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700149104"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt962"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15363"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00439"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2742"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21590"},{"key":"e_1_2_5_19_3","doi-asserted-by":"publisher","DOI":"10.1021\/ja206199d"},{"key":"e_1_2_5_19_4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414843111"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn403899y"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.054"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC07037B"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/am1006832"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/138620709789104933"},{"key":"e_1_2_5_24_1","first-page":"20","volume":"17","author":"DiConsiglio J.","year":"2008","journal-title":"Mater. Manag. Health Care"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2014.11.001"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.1.100"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800121-MCP200"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadma.201700057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201700057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:03:38Z","timestamp":1759741418000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.201700057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,12]]},"references-count":40,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/adma.201700057"],"URL":"https:\/\/doi.org\/10.1002\/adma.201700057","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,12]]},"article-number":"1700057"}}