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So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (<jats:bold>Nano\u2010IOLs<\/jats:bold>) is reported, in which the rim of commercially available IOLs (<jats:bold>C\u2010IOLs<\/jats:bold>) is decorated with silica coated Au nanorods (Au@SiO<jats:sub>2<\/jats:sub>), for high\u2010efficient prevention of PCO after cataract surgery. The <jats:bold>Nano\u2010IOLs<\/jats:bold> is capable of eliminating the residual lens epithelial cells (LECs) around <jats:bold>Nano\u2010IOLs<\/jats:bold> under mild laser treatment and block the formation of disordered LECs fibrosis, which eventually leads to the loss of vision. The <jats:bold>Nano\u2010IOLs<\/jats:bold> shows good biocompatibility as well as extraordinary region\u2010confined photothermal effect. In vivo studies reveal that PCO occurrence in rabbit models is about 30%\u201340% by using <jats:bold>Nano\u2010IOLs<\/jats:bold>, which is significantly lower than the control group that treated with <jats:bold>C\u2010IOLs<\/jats:bold> (100% PCO occurrence) 30 d postsurgery. To the best of our knowledge, it is the first example to integrate nanotechnology with intraocular implants aiming to clinically relevant PCO. Our findings indicate that spatial controllability of photothermal effect from nanomaterials may provide a unique way to intervene the PCO\u2010induced loss of vision.<\/jats:p>","DOI":"10.1002\/adma.201701617","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T03:24:37Z","timestamp":1500261877000},"source":"Crossref","is-referenced-by-count":54,"title":["Photothermal Ring Integrated Intraocular Lens for High\u2010Efficient Eye Disease Treatment"],"prefix":"10.1002","volume":"29","author":[{"given":"Yao\u2010Xin","family":"Lin","sequence":"first","affiliation":[{"name":"CAS Center for Excellence Nanoscience CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST)  No. 11 Beiyitiao Zhongguancun Beijing 100190 P. R. China"},{"name":"University of Chinese Academy of Sciences (UCAS)  No.19A Yuquan Road Beijing 100049 P. R. 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