{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:56:45Z","timestamp":1777931805697,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1A2A1A05005430"],"award-info":[{"award-number":["2016R1A2A1A05005430"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2016R1A2A1A05005430"],"award-info":[{"award-number":["2016R1A2A1A05005430"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201308440259"],"award-info":[{"award-number":["201308440259"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>One of the most heavily used methods in chemical and biological labeling, detection, and imaging is based on silver shell\u2010based enhancement on Au nanoparticles (AuNPs) that is useful for amplifying Rayleigh scattering, colorimetric signal, surface\u2010enhanced Raman scattering, and electrical signal, but poor structural controllability and nonspecific growth of silver shells have limited its applications, especially with respect to signal reproducibility and quantification. Here, a highly specific, well\u2010defined Cu nanopolyhedral shell overgrowth chemistry is developed with the aid of polyethyleneimine (PEI) on AuNPs, and the use of this PEI\u2010mediated Cu polyhedral nanoshell (CuP) chemistry is shown as a means of light\u2010scattering signal enhancement for the development of naked\u2010eye\u2010based highly sensitive and quantitative detections of DNA and viruses. Remarkably, these CuPs are exclusively formed on AuNPs in a controllable manner, with no noticeable nonspecific CuP growth. The findings enable to acquire clearly visible signals without analytic instrumentation, detectable down to 8 \u00d7 10<jats:sup>\u221215<\/jats:sup><jats:sc>m<\/jats:sc> of DNA (anthrax sequence) and 2700 copies of viruses (noroviruses in clinical stool samples) with broad dynamic ranges on archetypal assay platforms. This new method provides a general platform in controlling Cu shell nanostructures and their optical signals, and opens up revenues for highly reliable, quantitative onsite naked\u2010eye biodetection.<\/jats:p>","DOI":"10.1002\/adma.201702945","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:34:37Z","timestamp":1502094877000},"source":"Crossref","is-referenced-by-count":39,"title":["Sensitive, Quantitative Naked\u2010Eye Biodetection with Polyhedral Cu Nanoshells"],"prefix":"10.1002","volume":"29","author":[{"given":"Jae\u2010Ho","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouhong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyeong\u2010Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SungJun","family":"Park","sequence":"additional","affiliation":[{"name":"N\u2010Bio Seoul National University  Seoul 08826 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GwangPyo","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Graduate School of Public Health  Seoul 08826 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-8482","authenticated-orcid":false,"given":"Jwa\u2010Min","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Chemistry Seoul National University  Seoul 08826 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"e_1_2_4_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2162"},{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/b806051g"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja049384"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr2001178"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac2030199"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25710"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3661-4"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15274b"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2011.05.027"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.10.1209"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/31.12.6631001"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/05704928.2013.807817"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5485.1757"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.297.5586.1536"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067003"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/b313094k"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200901820"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.288"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.10157"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl050824k"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9018389"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/la0635092"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18333"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00482"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja501225p"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(89)90335-1"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.17.2236"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12206"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23346"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1257147"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2012.709820"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR06079J"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac500478g"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.13159"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3337"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201102151"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b02248"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac070867g"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadma.201702945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201702945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.201702945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201702945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T12:00:09Z","timestamp":1759752009000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.201702945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":38,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/adma.201702945"],"URL":"https:\/\/doi.org\/10.1002\/adma.201702945","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]},"article-number":"1702945"}}