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The nanofibers can be oriented by an appropriate positioning of the airbrush nozzle, and they can direct growth of neurites from rat dorsal root ganglion neurons. When loaded with the model protein lysozyme, the pSiNPs allow the generation of nanofiber scaffolds that carry and deliver the protein under physiologic conditions (phosphate\u2010buffered saline (PBS), at 37 \u00b0C) for up to 60 d, retaining 75% of the enzymatic activity over this time period. The mass loading of protein in the pSiNPs is 36%, and in the resulting polymer\/pSiNP scaffolds it is 3.6%. The use of pSiNPs that display intrinsic photoluminescence (from the quantum\u2010confined Si nanostructure) allows the polymer\/pSiNP composites to be definitively identified and tracked by time\u2010gated photoluminescence imaging. The remarkable ability of the pSiNPs to protect the protein payload from denaturation, both during processing and for the duration of the long\u2010term aqueous release study, establishes a model for the generation of biodegradable nanofiber scaffolds that can load and deliver sensitive biologics.<\/jats:p>","DOI":"10.1002\/adma.201706785","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T05:28:40Z","timestamp":1516771720000},"source":"Crossref","is-referenced-by-count":46,"title":["Oriented Nanofibrous Polymer Scaffolds Containing Protein\u2010Loaded Porous Silicon Generated by Spray Nebulization"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-0045","authenticated-orcid":false,"given":"Jonathan M.","family":"Zuidema","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of California  San Diego, 9500 Gilman Drive La Jolla CA 92093 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