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While targeted imaging often relies on antibody\u2010modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near\u2010infrared window (NIR\u2010II, 1000\u20131700 nm) shows promise in reaching sub\u2010centimeter depth with microscale resolution. Here, a novel peptide (named CP) conjugated NIR\u2010II fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker CD133. The click chemistry derived peptide\u2010dye (CP\u2010IRT dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor\u2010to\u2010normal tissue signal ratio (T\/NT &gt; 8). Importantly, the CP\u2010IRT probes are rapidly renal excreted (\u224887% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody\u2010dye probes. 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