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Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease\u2010environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ), hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) and sulfur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    ), and other gases such as carbon dioxide (CO\n                    <jats:sub>2<\/jats:sub>\n                    ),\n                    <jats:sc>dl<\/jats:sc>\n                    \u2010menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(\n                    <jats:sc>d<\/jats:sc>\n                    ,\n                    <jats:sc>l<\/jats:sc>\n                    \u2010lactic\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010glycolic acid), micelles, silica\/mesoporous silica, organosilica, MnO\n                    <jats:sub>2<\/jats:sub>\n                    , graphene, Bi\n                    <jats:sub>2<\/jats:sub>\n                    Se\n                    <jats:sub>3<\/jats:sub>\n                    , upconversion nanoparticles, CaCO\n                    <jats:sub>3<\/jats:sub>\n                    , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.\n                  <\/jats:p>","DOI":"10.1002\/adma.201801964","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T09:58:40Z","timestamp":1533117520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":346,"title":["Gas\u2010Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy"],"prefix":"10.1002","volume":"30","author":[{"given":"Luodan","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-3325","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"e_1_2_14_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b09974"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704307"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0116-7"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.25"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2995"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2721"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.45"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.54"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.15541\/jim20150488"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.17"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2011.95"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2933"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.15541\/jim20150424"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm03851b"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.05.008"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201104763"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.05.022"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.02.015"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000538"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar300028m"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.03.005"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/b818082b"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400372p"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200801716"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00424-8"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00471K"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.02.018"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b06814"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.280"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b02533"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/cs9932200233"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209855"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20817"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290133"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1329"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.04.027"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7BM00699C"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2016.07.028"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00248-5"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.139"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3064"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10269-017-2730-4"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605317113"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1367"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04871"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc704"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.171"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2397"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-90005-31"},{"key":"e_1_2_14_53_1","first-page":"1661","volume":"7","author":"Birner P.","year":"2001","journal-title":"Clin. 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