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Controllable generation of ATP in life is still an unrealized goal. Here, thylakoid fragments are recombined with lipid molecules to synthesize a synthetic\/biological hybrid proteoliposome, named highly efficient life\u2010support intracellular opto\u2010driven system (HELIOS) for the generation of ATP. With red light irradiation, HELIOS can improve the intracellular ATP concentration to 1.38\u20132.45 times in various cell lines. Moreover, it is noticed that HELIOS\u2010mediated ATP generation can comprehensively promote cell functions such as protein synthesis and insulin secretion. At organ and individual levels, it is also proved that HELIOS can rescue a mouse heart from myocardial infarction and sustain life of fasting zebrafish <jats:italic>Danio rerio<\/jats:italic> models. The photo\u2010powered artificial organelle can deepen our understanding of metabolism and enable the development of optical therapy that targets intracellular energy supply.<\/jats:p>","DOI":"10.1002\/adma.201805038","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T03:14:25Z","timestamp":1540955665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Photo\u2010Powered Artificial Organelles for ATP Generation and Life\u2010Sustainment"],"prefix":"10.1002","volume":"30","author":[{"given":"Di\u2010Wei","family":"Zheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry Wuhan University  Wuhan 430072 P. R. 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