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However, few studies report their \u201cenzyme\u2010like\u201d catalytic performance because it is difficult to prepare enzymatic nanosheets with small size and ultrathin thickness by current synthetic protocols. Herein, a novel one\u2010step wet\u2010chemical method is first proposed for protein\u2010directed synthesis of 2D MnO<jats:sub>2<\/jats:sub> nanosheets (M\u2010NSs), in which the size and thickness can be easily adjusted by the protein dosage. Then, a unique sono\u2010chemical approach is introduced for surface functionalization of the M\u2010NSs with high dispersity\/stability as well as metal\u2010cation\u2010chelating capacity, which can not only chelate <jats:sup>64<\/jats:sup>Cu radionuclides for positron emission tomography (PET) imaging, but also capture the potentially released Mn<jats:sup>2+<\/jats:sup> for enhanced biosafety. Interestingly, the resulting M\u2010NS exhibits excellent enzyme\u2010like activity to catalyze the oxidation of glucose, which represents an alternative paradigm of acute glucose oxidase for starving cancer cells and sensitizing them to thermal ablation. Featured with outstanding phototheranostic performance, the well\u2010designed M\u2010NS can achieve effective photoacoustic\u2010imaging\u2010guided synergistic starvation\u2010enhanced photothermal therapy. This study is expected to establish a new enzymatic phototheranostic paradigm based on small\u2010sized and ultrathin M\u2010NSs, which will broaden the application of 2D nanomaterials.<\/jats:p>","DOI":"10.1002\/adma.201900401","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T10:33:16Z","timestamp":1553769196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":182,"title":["Wet\/Sono\u2010Chemical Synthesis of Enzymatic Two\u2010Dimensional MnO<sub>2<\/sub> Nanosheets for Synergistic Catalysis\u2010Enhanced Phototheranostics"],"prefix":"10.1002","volume":"31","author":[{"given":"Wei","family":"Tang","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 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