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Unfortunately, currently available NIR\u2010II fluorophores exhibit slow excretion and low brightness, which prevents their potential medical applications. An atomic\u2010precision gold (Au) cluster with 25 gold atoms and 18 peptide ligands is presented. The Au\n                    <jats:sub>25<\/jats:sub>\n                    clusters show emission at 1100\u20131350 nm and the fluorescence quantum yield is significantly increased by metal\u2010atom doping. Bright gold clusters can penetrate deep tissue and can be applied in in vivo brain vessel imaging and tumor metastasis. Time\u2010resolved brain blood\u2010flow imaging shows significant differences between healthy and injured mice with different brain diseases in vivo. High\u2010resolution imaging of cancer metastasis allows for the identification of the primary tumor, blood vessel, and lymphatic metastasis. In addition, gold clusters with NIR\u2010II fluorescence are used to monitor high\u2010resolution imaging of kidney at a depth of 0.61 cm, and the quantitative measurement shows 86% of the gold clusters are cleared from body without any acute or long\u2010term toxicity at a dose of 100 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/adma.201901015","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T02:45:10Z","timestamp":1569984310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":431,"title":["Atomic\u2010Precision Gold Clusters for NIR\u2010II Imaging"],"prefix":"10.1002","volume":"31","author":[{"given":"Haile","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of Science Tianjin University  Tianjin 300354 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Chemistry Stanford University  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  10 Kent Ridge Crescent Singapore 119260 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of Science Tianjin University  Tianjin 300354 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlei","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Medicine Stanford University  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Chemistry Stanford University  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"He","sequence":"additional","affiliation":[{"name":"Department of Chemistry Stanford University  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Stanford University  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  10 Kent Ridge Crescent Singapore 119260 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulin","family":"Li","sequence":"additional","affiliation":[{"name":"Palo Alto Veterans Institute for Research, Inc. 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