{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:31:26Z","timestamp":1788399086727,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"publisher","award":["NTU\u2010SUG: M4081627"],"award-info":[{"award-number":["NTU\u2010SUG: M4081627"]}],"id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["RG133\/15 M4011559"],"award-info":[{"award-number":["RG133\/15 M4011559"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["2017\u2010T1\u2010002\u2010134\u2010RG147\/17"],"award-info":[{"award-number":["2017\u2010T1\u2010002\u2010134\u2010RG147\/17"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["MOE2016\u2010T2\u20101\u2010098"],"award-info":[{"award-number":["MOE2016\u2010T2\u20101\u2010098"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cancer theranostics holds potential promise for precision medicine; however, most existing theranostic nanoagents are simply developed by doping both therapeutic agents and imaging agent into one particle entity, and thus have an \u201calways\u2010on\u201d pharmaceutical effect and imaging signals regardless of their in vivo location. Herein, the development of an organic afterglow protheranostic nanoassembly (APtN) that specifically activates both the pharmaceutical effect and diagnostic signals in response to a tumor\u2010associated chemical mediator (hydrogen peroxide, H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) is reported. APtN comprises an amphiphilic macromolecule and a near\u2010infrared (NIR) dye acting as the H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010responsive afterglow prodrug and the afterglow initiator, respectively. Such a molecular architecture allows APtN to passively target tumors in living mice, specifically release the anticancer drug in the tumor, and spontaneously generate the uncaged afterglow substrate. Upon NIR light preirradiation, the afterglow initiator generates singlet oxygen to react and subsequently transform the uncaged afterglow substrate into an active self\u2010luminescent form. Thus, the intensity of generated afterglow luminescence is correlated with the drug release status, permitting real\u2010time in vivo monitoring of prodrug activation. This study proposes a background\u2010free design strategy toward activatable cancer theranostics.\n                  <\/jats:p>","DOI":"10.1002\/adma.201902672","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T12:38:21Z","timestamp":1560775101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["An Organic Afterglow Protheranostic Nanoassembly"],"prefix":"10.1002","volume":"31","author":[{"given":"Shasha","family":"He","sequence":"first","affiliation":[{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  70 Nanyang Drive Singapore 637457 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  70 Nanyang Drive Singapore 637457 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  70 Nanyang Drive Singapore 637457 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8064-6009","authenticated-orcid":false,"given":"Kanyi","family":"Pu","sequence":"additional","affiliation":[{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  70 Nanyang Drive Singapore 637457 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00140"},{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35342C"},{"key":"e_1_2_5_1_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01077"},{"key":"e_1_2_5_1_4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201600038"},{"key":"e_1_2_5_1_5","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2017.14"},{"key":"e_1_2_5_1_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2018.02.012"},{"key":"e_1_2_5_1_7","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900822"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0062"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201205292"},{"key":"e_1_2_5_2_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.08.010"},{"key":"e_1_2_5_2_4","first-page":"1806877","volume":"29","author":"Zhao L.","year":"2019","journal-title":"Adv. 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