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The key technologies and applications for conceptual sensor system fabrication are reported, as exemplified by the use of a stretchable sensor sheet completely conforming to an individual's body surface to realize a low\u2010noise wireless monitoring system (&lt;1 \u00b5V) that can be attached to the human forehead for recording electroencephalograms. The above system can discriminate between Alzheimer's disease and the healthy state, thus offering a rapid in\u2010home brain diagnosis possibility. Moreover, the introduction of metal nanowires to improve the transparency of the biocompatible sensor sheet allows one to wirelessly acquire electrocorticograms of nonhuman primates and simultaneously offers optogenetic stimulation such as toward\u2010the\u2010brain\u2013machine interface under free movement. 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