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Bionic nanocapsules are designed by cross\u2010linking polythymine and photoisomerized polyazobenzene (PETAzo) with adenine\u2010modified ZnS (ZnS\u2010A) nanoparticles (NPs) via nucleobase pairing. The ZnS\u2010A NPs convert X\u2010rays into UV radiation that isomerizes the azobenzene groups, which allows controlled diffusion of the active payloads across the bilayer membranes. In addition, the nucleobase pairing interactions between PETAzo and ZnS\u2010A prevent drug leakage during their in vivo circulation, which not only enhances tumor accumulation but also maintains stability. These nanocapsules with tunable permeability show prolonged retention, remotely controlled drug release, enhanced targeted accumulation, and effective antitumor effects, indicating their potential as an anticancer drug delivery system.<\/jats:p>","DOI":"10.1002\/adma.201903443","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T04:39:19Z","timestamp":1564979959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["X\u2010ray\u2010Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery"],"prefix":"10.1002","volume":"31","author":[{"given":"Hongzhang","family":"Deng","sequence":"first","affiliation":[{"name":"MOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University  Fuzhou 350108 China"},{"name":"Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National 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