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However, the functions of NK cells are often limited in the immunosuppressive tumor microenvironment (TME). Here, artificial NK cells (designated as aNK) with minor limitations of TME for specific tumor killing and renegade macrophage re\u2010education are created. The red blood cell membrane (RBCM) cloaks perfluorohexane (PFC) and glucose oxidase (GOX) to construct the aNK. The aNK can directly kill tumor cells by exhausting glucose and generating hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>). The generated H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> is also similar to cytokines and chemokines for recruiting immune cells and re\u2010educating survived macrophages to attack tumor cells. In addition, the oxygen\u2010carried PFC can strengthen the catalytic reaction of GOX and normalize the hypoxic TME. In vitro and in vivo experiments display that aNK with slight TME limitations exhibit efficient tumor inhibition and immune activation. The aNK will provide a new sight to treat tumor as the supplement of aggressive NK cells.<\/jats:p>","DOI":"10.1002\/adma.201904495","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:23:04Z","timestamp":1568006584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Artificial Natural Killer Cells for Specific Tumor Inhibition and Renegade Macrophage Re\u2010Education"],"prefix":"10.1002","volume":"31","author":[{"given":"Mei\u2010Zhen","family":"Zou","sequence":"first","affiliation":[{"name":"The Institute for Advanced Studies Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Long","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education &amp; Department of Chemistry Wuhan University  Wuhan 430072 P. R. 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