{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:05:44Z","timestamp":1790057144633,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21925402"],"award-info":[{"award-number":["21925402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21631005"],"award-info":[{"award-number":["21631005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21673104"],"award-info":[{"award-number":["21673104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51902136"],"award-info":[{"award-number":["51902136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JUSRP12003"],"award-info":[{"award-number":["JUSRP12003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M642155"],"award-info":[{"award-number":["2018M642155"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, a Cu<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic>OS@ZIF\u20108 nanostructure is fabricated to quantify the levels of hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) in living cells and in vivo. Zeolitic lmidazolate framework\u20108 (ZIF\u20108) is chosen as an encapsulation shell to improve the selectivity of this probe. Using this unique nanostructure, ultrasensitive quantification and bioimaging of H<jats:sub>2<\/jats:sub>S in living cells are successfully achieved. The lower limit of detection is 0.8 and 5.3 nmol per 10<jats:sup>6<\/jats:sup> cells for circular dichroism and fluorescence modes, respectively. It is found that the chiral Cu<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic>OS NPs transformed into achiral Cu<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic>S NPs contribute to the ultrasensitive detection. Notably, this probe can also be carried out to detect and track H<jats:sub>2<\/jats:sub>S levels in tumor\u2010bearing animals. The discoveries put forward for the creation of a detection platform for quantitative tracking and analysis in clinic.<\/jats:p>","DOI":"10.1002\/adma.201906580","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T06:37:31Z","timestamp":1586155051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Chiral Cu<i><sub>x<\/sub><\/i>OS@ZIF\u20108 Nanostructures for Ultrasensitive Quantification of Hydrogen Sulfide In Vivo"],"prefix":"10.1002","volume":"32","author":[{"given":"Aimeng","family":"Yuan","sequence":"first","affiliation":[{"name":"State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlong","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maozhong","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Kuang","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5639-7102","authenticated-orcid":false,"given":"Chuanlai","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"e_1_2_4_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00212A"},{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b02767"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201708005"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712528"},{"key":"e_1_2_4_5_1","first-page":"7510","volume":"90","author":"Jiao X. Y.","year":"2018","journal-title":"Chem. Soc. Rev"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201800515"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b00752"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201505025"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201604892"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00321"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC03856E"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b03248"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00528H"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.01.009"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5302"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b10309"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00755"},{"key":"e_1_2_4_18_1","author":"Hao C.","journal-title":"Adv. Mater."},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00879A"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201803291"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00930A"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201800202"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b04477"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b11856"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08714"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b01445"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201803966"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201711600"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107025"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwy029"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b11720"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201207701"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201104236"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b04196"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja203661j"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadma.201906580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201906580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.201906580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201906580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:14:07Z","timestamp":1759763647000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.201906580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,6]]},"references-count":35,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/adma.201906580"],"URL":"https:\/\/doi.org\/10.1002\/adma.201906580","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,6]]},"assertion":[{"value":"2019-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1906580"}}