{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:00:15Z","timestamp":1792609215723,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21772084"],"award-info":[{"award-number":["21772084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tumor\u2010lymph node (LN) metastasis is the dominant prognostic factor for tumor staging and therapeutic decision\u2010making. However, concurrently visualizing metastasis and performing imaging\u2010guided lymph node surgery is challenging. Here, a multiplexed\u2010near\u2010infrared\u2010II (NIR\u2010II) in vivo imaging system using nonoverlapping NIR\u2010II probes with markedly suppressed photon scattering and zero\u2010autofluorescence is reported, which enables visualization of the metastatic tumor and the tumor metastatic proximal LNs resection. A bright and tumor\u2010seeking donor\u2013acceptor\u2013donor (D\u2010A\u2010D) dye, IR\u2010FD, is screened for primary\/metastatic tumor imaging in the NIR\u2010IIa (1100\u20131300 nm) window. This optimized D\u2010A\u2010D dye exhibits greatly improved quantum yield of organic D\u2010A\u2010D fluorophores in aqueous solutions (\u22486.0%) and good in vivo performance. Ultrabright PbS\/CdS core\/shell quantum dots (QDs) with dense polymer coating are used to visualize cancer\u2010invaded sentinel LNs in the NIR\u2010IIb (&gt;1500 nm) window. Compared to clinically used indocyanine green, the QDs show superior brightness and photostability (no obvious bleaching even after continuous laser irradiation for 5 h); thus, only a picomolar dose is required for sentinel LNs detection. This combination of dual\u2010NIR\u2010II image\u2010guided surgery can be performed under bright light, adding to its convenience and appeal in clinical use.<\/jats:p>","DOI":"10.1002\/adma.201907365","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T11:02:10Z","timestamp":1580900530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":235,"title":["Multiplexed NIR\u2010II Probes for Lymph Node\u2010Invaded Cancer Detection and Imaging\u2010Guided Surgery"],"prefix":"10.1002","volume":"32","author":[{"given":"Rui","family":"Tian","sequence":"first","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin University  Changchun 130061 P. R. China"},{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Shenzhen Key Laboratory of Printed Organic Electronics Southern University of Science and Technology  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoujun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin University  Changchun 130061 P. R. China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lau","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Shenzhen Key Laboratory of Printed Organic Electronics Southern University of Science and Technology  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisen","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Chandra","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Shenzhen Key Laboratory of Printed Organic Electronics Southern University of Science and Technology  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhang","family":"Deng","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Niu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology  Wuhan 430070 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Antaris","sequence":"additional","affiliation":[{"name":"Intuitive Surgical  Kifer Rd Sunnyvale CA 94086 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Hettie","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford (MIPS) Department of Radiology Stanford University School of Medicine  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongye","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Shenzhen Key Laboratory of Printed Organic Electronics Southern University of Science and Technology  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-0870","authenticated-orcid":false,"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.31225"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3622"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27995"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35346"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30448-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.3502"},{"key":"e_1_2_5_7_1","first-page":"51","volume":"10","author":"Stoffels I.","year":"2012","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-016-0010"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706856"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b03062"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801140"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801778"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.37672"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802394"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.31332"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909560"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00001H"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900321"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802546"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718917115"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201706974"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201801226"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806153115"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0056"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703451"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0221-0"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201703296"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05503"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00234G"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3199"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12749"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41566-019-0437-z"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05113-8"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201804956"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b10334"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705799"},{"key":"e_1_2_5_37_1","first-page":"15269","volume":"10","author":"Wang S.","year":"2019","journal-title":"Nat. Commun."},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15269"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0271"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00494C"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC01153B"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617990114"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03505-4"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-018-2210-x"},{"key":"e_1_2_5_45_1","first-page":"eaaw0627","volume":"5","author":"Tian R.","year":"2019","journal-title":"Sci. Adv."},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-017-0007-z"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07851-z"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25383-y"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801331"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201806853"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.36739"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34390"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1340"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3780"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0398-7"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14702"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.30268"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadma.201907365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201907365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.201907365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201907365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:06:39Z","timestamp":1759784799000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.201907365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/adma.201907365"],"URL":"https:\/\/doi.org\/10.1002\/adma.201907365","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,5]]},"assertion":[{"value":"2019-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1907365"}}