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Inhibition of islet\u2010specific autoreactive T cells to rescue \u03b2\u2010cells is a promising approach to treat new\u2010onset T1D. The immune checkpoint signal axis programmed death\u20101\/programmed death\u2010ligand 1 (PD\u20101\/PD\u2010L1) can effectively regulate the activity of T cells and prevent autoimmune attack. Here, megakaryocyte progenitor cells are genetically engineered to overexpress PD\u2010L1 to produce immunosuppressive platelets. The PD\u2010L1\u2010overexpressing platelets (designated PD\u2010L1 platelets) accumulate in the inflamed pancreas and may suppress the activity of pancreas autoreactive T cells in newly hyperglycemic non\u2010obese diabetic (NOD) mice, protecting the insulin\u2010producing \u03b2\u2010cells from destruction. Moreover, PD\u2010L1 platelet treatment also increases the percentage of the regulatory T cells (Tregs) and maintains immune tolerance in the pancreas. 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