{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:13:58Z","timestamp":1787163238946,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"publisher","award":["M4081627"],"award-info":[{"award-number":["M4081627"]}],"id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901803"],"award-info":[{"award-number":["81901803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20190811"],"award-info":[{"award-number":["BK20190811"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Photoacoustic (PA) imaging agents detect disease tissues and biomarkers with increased penetration depth and enhanced spatial resolution relative to traditional optical imaging, and thus hold great promise for clinical applications. However, existing PA imaging agents often encounter the issues of slow body excretion and low\u2010signal specificity, which compromise their capability for in vivo detection. Herein, a fluoro\u2010photoacoustic polymeric renal reporter (FPRR) is synthesized for real\u2010time imaging of drug\u2010induced acute kidney injury (AKI). FPRR simultaneously turns on both near\u2010infrared fluorescence (NIRF) and PA signals in response to an AKI biomarker (\u03b3\u2010glutamyl transferase) with high sensitivity and specificity. In association with its high renal clearance efficiency (78% at 24 h post\u2010injection), FPRR can detect cisplatin\u2010induced AKI at 24 h post\u2010drug treatment through both real\u2010time imaging and optical urinalysis, which is 48 h earlier than serum biomarker elevation and histological changes. More importantly, the deep\u2010tissue penetration capability of PA imaging results in a signal\u2010to\u2010background ratio that is 2.3\u2010fold higher than NIRF imaging. Thus, the study not only demonstrates the first activatable PA probe for real\u2010time sensitive imaging of kidney function at molecular level, but also highlights the polymeric probe structure with high renal clearance.<\/jats:p>","DOI":"10.1002\/adma.201908530","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T07:35:05Z","timestamp":1583480105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Fluoro\u2010Photoacoustic Polymeric Renal Reporter for Real\u2010Time Dual Imaging of Acute Kidney Injury"],"prefix":"10.1002","volume":"32","author":[{"given":"Penghui","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  70 Nanyang Drive Singapore 637457 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenhua","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"He","sequence":"additional","affiliation":[{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  70 Nanyang Drive Singapore 637457 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Miao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8064-6009","authenticated-orcid":false,"given":"Kanyi","family":"Pu","sequence":"additional","affiliation":[{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  70 Nanyang Drive Singapore 637457 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,6]]},"reference":[{"key":"e_1_2_4_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1216210"},{"key":"e_1_2_4_1_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2387"},{"key":"e_1_2_4_1_3","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1220"},{"key":"e_1_2_4_1_4","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00765A"},{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3929"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2014.130"},{"key":"e_1_2_4_3_2","author":"Jeevarathinam A. S.","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn302042y"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl100890d"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00242"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201808166"},{"key":"e_1_2_4_6_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b08616"},{"key":"e_1_2_4_6_4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b02106"},{"key":"e_1_2_4_6_5","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201700125"},{"key":"e_1_2_4_6_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.03.003"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201903461"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b05906"},{"key":"e_1_2_4_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801778"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2019.03.001"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.35.000270"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.231"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00641"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201505681"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00001H"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b10353"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201604764"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2013.302"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201803321"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13628"},{"key":"e_1_2_4_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201710727"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b10504"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2015.06.006"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2013.11.003"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01320"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02050309"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-018-0038-3"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1340"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201007321"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja201930p"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.170"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl803405h"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201104104"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913667107"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0378-4"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201910137"},{"key":"e_1_2_4_27_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201911859"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201901525"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198601093140207"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11921112"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0392-z"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.5935\/0101-2800.20130052"},{"key":"e_1_2_4_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000142928"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.76"},{"key":"e_1_2_4_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365516409060486"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.049"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015070827"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-007-0597-2"},{"key":"e_1_2_4_37_1","first-page":"4805853","volume":"2019","author":"Huang S.","year":"2019","journal-title":"BioMed. Res. Int."}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadma.201908530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201908530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.201908530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201908530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:42:31Z","timestamp":1759765351000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.201908530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,6]]},"references-count":59,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/adma.201908530"],"URL":"https:\/\/doi.org\/10.1002\/adma.201908530","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,6]]},"assertion":[{"value":"2019-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1908530"}}