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Herein, an integrative strategy for cancer therapy against solid tumors is reported, in which alterations in the cleft of IS, following the secretion of acidic granular content, are utilized as a trigger for the delivery of chemotherapeutic drugs. NK cells are decorated with the IS\u2010environment\u2010responsive micellar system to ensure the release of the payload when they attack cancer cells. Using this strategy, the immunological cytotoxic killing effect of NK cells against solid tumors is reinforced with the site\u2010specific diffusion of chemotherapeutic agents. Harnessing the intrinsic mechanism for the recognition of abnormal cells and the tumor\u2010homing effect of NK cells limit the adverse systemic effects of chemotherapeutic drugs. This approach may provide a pragmatic platform for the universal and effective utilization of IS formation.<\/jats:p>","DOI":"10.1002\/adma.202000020","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T01:45:52Z","timestamp":1587519952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Harnessing the Formation of Natural Killer\u2013Tumor Cell Immunological Synapses for Enhanced Therapeutic Effect in Solid Tumors"],"prefix":"10.1002","volume":"32","author":[{"given":"Sooseok","family":"Im","sequence":"first","affiliation":[{"name":"School of Interdisciplinary Bioscience and Bioengineering (I\u2010Bio) Pohang University of Science and Technology (POSTECH)  Pohang 37673 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Chemistry POSTECH\u2010Catholic Biomedical Engineering Institute Pohang University of Science and Technology (POSTECH)  Pohang 37673 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurusamy","family":"Saravanakumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry POSTECH\u2010Catholic Biomedical Engineering Institute Pohang University of Science and Technology (POSTECH)  Pohang 37673 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junseok","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Interdisciplinary Bioscience and Bioengineering (I\u2010Bio) Pohang University of Science and Technology (POSTECH)  Pohang 37673 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeoul","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Chemistry POSTECH\u2010Catholic Biomedical Engineering Institute Pohang University of Science and Technology (POSTECH)  Pohang 37673 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry POSTECH\u2010Catholic Biomedical Engineering Institute Pohang University of Science and Technology (POSTECH)  Pohang 37673 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry POSTECH\u2010Catholic Biomedical Engineering Institute Pohang University of Science and Technology (POSTECH)  Pohang 37673 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsang","family":"Doh","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zung Yoon","family":"Yang","sequence":"additional","affiliation":[{"name":"GI Cell, Inc.  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