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Current diagnostic approaches for VSCs can detect the existence and concentrations, yet are not capable of locating the dental lesion sites. Herein, the development of a unique approach for accurately locating dental lesion sites using a fluorescent mouthguard consisting of the zinc oxide\u2013poly(dimethylsiloxane) (ZnO\u2010PDMS) nanocomposite to detect the local release of VSCs is reported. The ZnO\u2010PDMS mouthguard displays a highly sensitive and selective response to VSCs, and exhibits high fluorescent stability, good biocompatibility, and low biological toxicity in normal physiological environments. Then, the wearable ZnO\u2010PDMS mouthguard is demonstrated to be able to identify the precise locations of lesion sites in human subjects. Combined with image analysis, the mouthguards successfully uncover the precise locations of dental caries, allowing convenient screening of hidden dental lesion sites that are oftentimes omitted by dentists. Due to low cost, long\u2010term stability, and good patient compliance, the proposed wearable mouthguard is suitable for large\u2010scale production and enables widely applicable, preliminary yet accurate screening of dental lesions prior to dental clinics and routine physical examinations.<\/jats:p>","DOI":"10.1002\/adma.202000060","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T14:14:56Z","timestamp":1585836896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["A Transparent, Wearable Fluorescent Mouthguard for High\u2010Sensitive Visualization and Accurate Localization of Hidden Dental Lesion Sites"],"prefix":"10.1002","volume":"32","author":[{"given":"Xuemeng","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province School of Biomedical Engineering Sun Yat\u2010sen University  Guangzhou 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