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The multicompartment micromotors display strong gastric\u2010powered propulsion with tunable lifetime depending on the Zn segment length. Such propulsion significantly enhances the motor distribution and retention in the gastric tissues, by pushing and impinging the front\u2010end cargo segment onto the stomach wall. Once the micromotor penetrates the gastric mucosa (pH \u2265 6.0), its pH\u2010responsive cap dissolves, promoting the autonomous localized cargo release. The fabrication process, physicochemical properties, and propulsion behavior are systematically tested and discussed. Using a mouse model, the multicompartment motors, loaded with a model cargo, demonstrate a homogeneous cargo distribution along with approximately four\u2010fold enhanced retention in the gastric lining compared to monocompartment motors, while showing no apparent toxicity. Therapeutic payloads can also be loaded into the pH\u2010responsive cap, in addition to the gelatin\u2010based compartment, leading to concurrent delivery and sequential release of dual cargos toward combinatorial therapy. Overall, this multicompartment micromotor system provides unique features and advantages that will further advance the development of synthetic micromotors for active transport and localized delivery of biomedical cargos.<\/jats:p>","DOI":"10.1002\/adma.202000091","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T01:27:32Z","timestamp":1589765252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Multicompartment Tubular Micromotors Toward Enhanced Localized Active Delivery"],"prefix":"10.1002","volume":"32","author":[{"given":"Berta","family":"Esteban\u2010Fern\u00e1ndez de \u00c1vila","sequence":"first","affiliation":[{"name":"Department of Nanoengineering University of California San Diego  La Jolla CA 92093 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-2866","authenticated-orcid":false,"given":"Miguel 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