{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:15:37Z","timestamp":1790554537361,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600809"],"award-info":[{"award-number":["31600809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31640027"],"award-info":[{"award-number":["31640027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51803049"],"award-info":[{"award-number":["51803049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1804139"],"award-info":[{"award-number":["U1804139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX201700070"],"award-info":[{"award-number":["BX201700070"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1111611"],"award-info":[{"award-number":["GNT1111611"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1166024"],"award-info":[{"award-number":["GNT1166024"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Small interfering RNA (siRNA) has been considered as a highly promising therapeutic agent for human cancer treatment including glioblastoma (GBM), which is a fatal disease without effective therapy methods. However, siRNA\u2010based GBM therapy is seriously hampered by a number of challenges in siRNA brain delivery including poor stability, short blood circulation, low blood\u2013brain barrier (BBB) penetration, and tumor accumulation, as well as inefficient siRNA intracellular release. Herein, an Angiopep\u20102 (Ang) functionalized intracellular\u2010environment\u2010responsive siRNA nanocapsule (Ang\u2010NC<jats:sub>ss<\/jats:sub>(siRNA)) is successfully developed as a safe and efficient RNAi agent to boost siRNA\u2010based GBM therapy. The experimental results demonstrate that the developed Ang\u2010NC<jats:sub>ss<\/jats:sub>(siRNA) displays long circulation in plasma, efficient BBB penetration capability, and GBM accumulation and retention, as well as responsive intracellular siRNA release due to the unique design of small size (25 nm) with polymeric shell for siRNA protection, Ang functionalization for BBB crossing and GBM targeting, and disulfide bond as a linker for intracellular\u2010environment\u2010responsive siRNA release. Such superior properties of Ang\u2010NC<jats:sub>ss<\/jats:sub>(siRNA) result in outstanding growth inhibition of orthotopic U87MG xenografts without causing adverse effects, achieving remarkably improved survival benefits. The developed siRNA nanocapsules provide a new strategy for RNAi therapy of GBM and beyond.<\/jats:p>","DOI":"10.1002\/adma.202000416","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T08:41:42Z","timestamp":1588754502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":168,"title":["Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment"],"prefix":"10.1002","volume":"32","author":[{"given":"Yan","family":"Zou","sequence":"first","affiliation":[{"name":"Henan\u2010Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"},{"name":"Centre for Motor Neuron Disease Research Department of Biomedical Sciences Faculty of Medicine and Health Sciences Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhong","family":"Sun","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengnan","family":"Yan","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Motor Neuron Disease Research Department of Biomedical Sciences Faculty of Medicine and Health Sciences Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"Chung","sequence":"additional","affiliation":[{"name":"Centre for Motor Neuron Disease Research Department of Biomedical Sciences Faculty of Medicine and Health Sciences Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-1062","authenticated-orcid":false,"given":"Bingyang","family":"Shi","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie University Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"},{"name":"Centre for Motor Neuron Disease Research Department of Biomedical Sciences Faculty of Medicine and Health Sciences Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.0119"},{"key":"e_1_2_3_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1432-1"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0003-5"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3590"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.01.005"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716435"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-016-1497-x"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15144"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201501167"},{"key":"e_1_2_3_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201409161"},{"key":"e_1_2_3_5_4","doi-asserted-by":"publisher","DOI":"10.1021\/ja304649a"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03705-y"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0214-1"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0012-9"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.280"},{"key":"e_1_2_3_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.07.005"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903637"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201504661"},{"key":"e_1_2_3_8_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b01101"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aar8409"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201601441"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12501"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510844"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b09602"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07195"},{"key":"e_1_2_3_11_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201709485"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.01.006"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2634"},{"key":"e_1_2_3_12_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.06.011"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201803717"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201800316"},{"key":"e_1_2_3_13_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b05265"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705436"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201500894"},{"key":"e_1_2_3_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706307"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.341"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903277"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MH00342K"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07195"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003601"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621240114"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201603794"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201806466"}],"updated-by":[{"DOI":"10.1002\/adma.202300777","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000}}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadma.202000416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202000416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202000416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202000416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:52:55Z","timestamp":1759758775000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202000416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,6]]},"references-count":43,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/adma.202000416"],"URL":"https:\/\/doi.org\/10.1002\/adma.202000416","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1002\/adma.202300777","asserted-by":"object"}]},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,6]]},"assertion":[{"value":"2020-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000416"}}