{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:29:23Z","timestamp":1790274563558,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFA0203700"],"award-info":[{"award-number":["2016YFA0203700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51722211"],"award-info":[{"award-number":["51722211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21835007"],"award-info":[{"award-number":["21835007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51902334"],"award-info":[{"award-number":["51902334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51672303"],"award-info":[{"award-number":["51672303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["18XD1404300"],"award-info":[{"award-number":["18XD1404300"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In situ toxification of less toxic substance for the generation of effective anticarcinogens at the specific tumor tissue has been a novel paradigm for combating cancer. Significant efforts have been recently dedicated to turning clinical\u2010approved drugs into anticancer agents in specific tumor microenvironment by chemical reactions. Herein, a hollow mesoporous Prussian blue (HMPB)\u2010based therapeutic nanoplatform, denoted as DSF@PVP\/Cu\u2010HMPB, is constructed by encapsulating alcohol\u2010abuse drug disulfiram (DSF) into the copper\u2010enriched and polyvinylpyrrolidone (PVP)\u2010decorated HMPB nanoparticles to achieve in situ chemical reaction\u2010activated and hyperthermia\u2010amplified chemotherapy of DSF. Upon tumor accumulation of DSF@PVP\/Cu\u2010HMPB, the endogenous mild acidity in tumor condition triggers the biodegradation of the HMPB nanoparticle and the concurrent co\u2010releases of DSF and Cu<jats:sup>2+<\/jats:sup>, thus forming cytotoxic bis(<jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010diethyl dithiocarbamato)copper(II) complexes (CuL<jats:sub>2<\/jats:sub>) via DSF\u2010Cu<jats:sup>2+<\/jats:sup> chelating reaction. Moreover, by the intrinsic photothermal\u2010conversion effect of PVP\/Cu\u2010HMPBs, the anticancer effect of DSF is augmented by the hyperthermia generated upon near\u2010infrared irradiation, thus inducing remarkable cell apoptosis in vitro and tumor elimination in vivo on both subcutaneous and orthotopic tumor\u2010bearing models. This strategy of in situ drug transition by chemical chelation reaction and photothermal\u2010augmentation provides a promising paradigm for designing novel cancer\u2010therapeutic nanoplatforms.<\/jats:p>","DOI":"10.1002\/adma.202000542","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T07:37:41Z","timestamp":1583998661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Copper\u2010Enriched Prussian Blue Nanomedicine for In Situ Disulfiram Toxification and Photothermal Antitumor Amplification"],"prefix":"10.1002","volume":"32","author":[{"given":"Wencheng","family":"Wu","sequence":"first","affiliation":[{"name":"The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luodan","family":"Yu","sequence":"additional","affiliation":[{"name":"The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinying","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital Ultrasound Research and Education Institute Tongji University Cancer Center Tongji University School of Medicine  Shanghai 200072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heliang","family":"Yao","sequence":"additional","affiliation":[{"name":"The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8790-195X","authenticated-orcid":false,"given":"Jianlin","family":"Shi","sequence":"additional","affiliation":[{"name":"The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"e_1_2_4_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1730-1"},{"key":"e_1_2_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_4_1_3","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag2942"},{"key":"e_1_2_4_1_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0005-8"},{"key":"e_1_2_4_1_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2019.02.003"},{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3461"},{"key":"e_1_2_4_2_2","first-page":"62","volume":"64","author":"Murakami M.","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"e_1_2_4_2_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1226338"},{"key":"e_1_2_4_2_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0567-y"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2017.24"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234139"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11193-x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.46"},{"key":"e_1_2_4_4_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav2588"},{"key":"e_1_2_4_4_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09566-3"},{"key":"e_1_2_4_4_5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07197-8"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25016"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC04767B"},{"key":"e_1_2_4_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807582"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03503"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27482"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.005"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b12070"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201503381"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201403991"},{"key":"e_1_2_4_8_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13447-0"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/am507443p"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201105190"},{"key":"e_1_2_4_9_3","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2118"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706825"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsenergylett.9b00573"},{"key":"e_1_2_4_10_3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4007"},{"key":"e_1_2_4_10_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b04579"},{"key":"e_1_2_4_10_5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802510"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201605795"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic50177a008"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00719H"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0589-5"},{"key":"e_1_2_4_12_3","first-page":"1901307","volume":"7","author":"Wu J. R.","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0373-6"},{"key":"e_1_2_4_14_1","first-page":"6","volume":"148","author":"Daly A. C.","year":"2019","journal-title":"Nat. Rev. Mater."},{"key":"e_1_2_4_15_1","first-page":"4491","volume":"30","author":"Lin H.","year":"2017","journal-title":"Adv. Mater."},{"key":"e_1_2_4_15_2","first-page":"9467","volume":"11","author":"Dai C.","year":"2017","journal-title":"Chem. Mater."}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadma.202000542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202000542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202000542","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202000542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:42:43Z","timestamp":1759765363000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202000542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,12]]},"references-count":43,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/adma.202000542"],"URL":"https:\/\/doi.org\/10.1002\/adma.202000542","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,12]]},"assertion":[{"value":"2020-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000542"}}