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Unfortunately, the humoral concentrations of most biotargets generally vary within rather limited scopes between normal and pathological states, while most literature\u2010reported biosensors can detect large spans of targets concentrations, but are less sensitive to small concentration changes, which consequently make them mostly unsatisfactory or even unreliable in distinguishing positives from negatives. Herein, a novel strategy of precisely quantifying the small concentration changes of a certain biotarget by editing the dynamic ranges and sensitivities of a lanthanide\u2010based metal\u2013organic framework (Eu\u2010ZnMOF) biosensor is reported. By elaborately tailoring the biosensor's structure and surface areas, the tunable Eu\u2010ZnMOF is developed with remarkably enhanced response slope within the \u201coptimized useful detection window,\u201d enabling it to serve as a powerful signal amplifier (87.2\u2010fold increase) for discriminating the small concentration variation of urinary vanillylmandelic acid (an early pathological signature of pheochromocytoma) within only three times between healthy and diseased subjects. This study provides a facile approach to edit the biosensors' performances through structure engineering, and exhibits promising perspectives for future clinical application in the non\u2010invasive and accurate diagnosis of severe diseases.<\/jats:p>","DOI":"10.1002\/adma.202000791","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T02:41:25Z","timestamp":1587955285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Structure Engineering of a Lanthanide\u2010Based Metal\u2013Organic Framework for the Regulation of Dynamic Ranges and Sensitivities for Pheochromocytoma Diagnosis"],"prefix":"10.1002","volume":"32","author":[{"given":"Ji\u2010Na","family":"Hao","sequence":"first","affiliation":[{"name":"Laboratory of Low\u2010Dimensional Materials Chemistry Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical Nanomaterials School of Materials Science and Engineering Frontier Science Center of the Materials Biology and Dynamic Chemistry East China University of Science and Technology  Shanghai 200237 P. 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