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However, inhomogeneous signal attenuation due to tissue absorption and scattering hampers its application for accurate in vivo biosensing. Here, lifetime\u2010based in situ hepatocellular carcinoma (HCC) detection in NIR\u2010II region is presented using a tumor\u2010microenvironment (peroxynitrite, ONOO<jats:sup>\u2212<\/jats:sup>)\u2010responsive lanthanide\u2013cyanine F\u00f6rster resonance energy transfer (FRET) nanosensor. A specially designed ONOO<jats:sup>\u2212<\/jats:sup>\u2010responsive NIR\u2010II dye, MY\u20101057, is synthesized as the FRET acceptor. Robust lifetime sensing is demonstrated to be independent of tissue penetration depth. Tumor lesions are accurately distinguished from normal tissue due to the recovery lifetime. Magnetic resonance imaging and liver dissection results illustrate the reliability of lifetime\u2010based detection in single and multiple HCC models. Moreover, the ONOO<jats:sup>\u2212<\/jats:sup> amount can be calculated according to the standard curve.<\/jats:p>","DOI":"10.1002\/adma.202001172","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T08:32:51Z","timestamp":1591173171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":229,"title":["A Tumor\u2010Microenvironment\u2010Responsive Lanthanide\u2013Cyanine FRET Sensor for NIR\u2010II Luminescence\u2010Lifetime In Situ Imaging of Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"32","author":[{"given":"Mengyao","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers and iChem Fudan University  Shanghai 200433 P. R. 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