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However, maintaining efficacy at low doses to minimize toxicity is a critical for clinical applications. Tuning the surface strain of metallic nanoparticles can enhance catalytic reactivity, which has rarely been demonstrated in metal oxide nanomaterials. Here, it is shown that inducing surface strains of CeO<jats:sub>2<\/jats:sub>\/Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanocrystals produces highly catalytic antioxidants that can protect tissue\u2010resident stem cells from irradiation\u2010induced ROS damage. Manganese ions deposited on the surface of cerium oxide (CeO<jats:sub>2<\/jats:sub>) nanocrystals form strained layers of manganese oxide (Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>) islands, increasing the number of oxygen vacancies. CeO<jats:sub>2<\/jats:sub>\/Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanocrystals show better catalytic activity than CeO<jats:sub>2<\/jats:sub> or Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> alone and can protect the regenerative capabilities of intestinal stem cells in an organoid model after a lethal dose of irradiation. A small amount of the nanocrystals prevents acute radiation syndrome and increases the survival rate of mice treated with a lethal dose of total body irradiation.<\/jats:p>","DOI":"10.1002\/adma.202001566","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T14:38:14Z","timestamp":1591799894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Epitaxially Strained CeO<sub>2<\/sub>\/Mn<sub>3<\/sub>O<sub>4<\/sub> Nanocrystals as an Enhanced Antioxidant for Radioprotection"],"prefix":"10.1002","volume":"32","author":[{"given":"Sang Ihn","family":"Han","sequence":"first","affiliation":[{"name":"Center for Nanoparticle Research Institute for Basic Science (IBS)  Seoul 08826 Republic of Korea"},{"name":"School of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University  Seoul 08826 Republic of 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