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The use of immunogenic cell death (ICD)\u2010inducing agents has potential to potentiate antitumor immune responses, but is tremendously hampered by the poor delivery efficiency. Herein, a tumor\u2010activated size\u2010enlargeable bioinspired lipoprotein of oxaliplatin (TA\u2010OBL) is designed to access cancer cells and boost the ICD\u2010induced antitumor immunity for synergizing immune\u2010checkpoint blockades (ICBs)\u2010mediated immunotherapy. TA\u2010OBL is constructed by integrating a legumain\u2010sensitive melittin conjugate for improving intratumoral permeation and cancer cell accessibility, a pH\u2010sensitive phospholipid for triggering size\u2010enlargement and drug release in intracellular acidic environments, a nitroreductase\u2010sensitive hydrophobic oxaliplatin prodrug (N\u2010OXP) for eliciting antitumor immunity into the bioinspired nano\u2010sized lipoprotein system. TA\u2010OBL treatment produced robust antitumor immune responses and its combination with ICBs demonstrates strong therapeutic benefits with delayed tumor growth and extended survival rate, making it a promising delivery nanoplatform to elicit antitumor immunity for cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/adma.202002380","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:56:49Z","timestamp":1598605009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Tumor\u2010Activated Size\u2010Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti\u2010Tumor Immune Responses"],"prefix":"10.1002","volume":"32","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"State key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"},{"name":"School of Life Science and 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