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However, the relatively deficient catalytic activity of nanozymes in the tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria\u2010like PEG\/Ce\u2010Bi@DMSN nanozyme is developed by coating uniform Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    nanorods (NRs) with dendritic mesoporous silica (Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @DMSN) and then decorating ultrasmall ceria nanozymes into the large mesopores of Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @DMSN. The nanozymes exhibit dual enzyme\u2010mimic catalytic activities (peroxidase\u2010mimic and catalase\u2010mimic) under acidic conditions that can regulate the TME, that is, simultaneously elevate oxidative stress and relieve hypoxia. In addition, the nanozymes can effectively consume the overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) is introduced to synergistically improve the dual enzyme\u2010mimicking catalytic activities and depletion of the overexpressed GSH in the tumors by photonic hyperthermia. This is achieved by taking advantage of the desirable light absorbance in the second near\u2010infrared (NIR\u2010II) window of the PEG\/Ce\u2010Bi@DMSN nanozymes. Subsequently the reactive oxygen species (ROS)\u2010mediated therapeutic efficiency is significantly improved. Therefore, this study provides a proof of concept of hyperthermia\u2010augmented multi\u2010enzymatic activities of nanozymes for tumor ablation.\n                  <\/jats:p>","DOI":"10.1002\/adma.202002439","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T04:10:58Z","timestamp":1600056658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":573,"title":["GSH\u2010Depleted Nanozymes with Hyperthermia\u2010Enhanced Dual Enzyme\u2010Mimic Activities for Tumor Nanocatalytic Therapy"],"prefix":"10.1002","volume":"32","author":[{"given":"Shuming","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. 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