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Nanomaterial\u2010based photothermal therapy (PTT) and magnetic hyperthermia (MHT), as highly effective and noninvasive treatment models, offer advantages over other strategies in the treatment of different types of tumors. However, both PTT and MHT cannot completely cure cancer due to recurrence and distal metastasis. In recent years, cancer immunotherapy has attracted widespread attention owing to its capability to activate the body's own natural defense to identify, attack, and eradicate cancer cells. Significant efforts have been devoted to studying the activated immune responses caused by hyperthermia\u2010ablated tumors. In this article, the synergistic mechanism of HTT in immunotherapy, including immunogenic cell death and reversal of the immunosuppressive tumor microenvironment is discussed. The reports of the combination of HTT or HTT\u2010based multimodal therapy with immunotherapy, including immunoadjuvant exploitation, immune checkpoint blockade therapy, and adoptive cellular immunotherapy are summarized. As highlighted, these strategies could achieve synergistically enhanced therapeutic outcomes against both primary tumors and metastatic lesions, prevent cancer recurrence, and prolong the survival period. Finally, current challenges and prospective developments in HTT\u2010synergized immunotherapy are also reviewed.<\/jats:p>","DOI":"10.1002\/adma.202004788","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T04:58:15Z","timestamp":1606885095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":432,"title":["Recent Advances in Hyperthermia Therapy\u2010Based Synergistic Immunotherapy"],"prefix":"10.1002","volume":"33","author":[{"given":"Mengyu","family":"Chang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. China"},{"name":"School of Applied Chemistry and Engineering University of Sciences and Technology of China  Hefei 230026 P. R. 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