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Effective accumulation of activatable photosensitizers (PSs) in phagocytes to realize selective imaging and on\u2010demand photodynamic ablation of bacteria is of great scientific and practical interests for precise bacteria diagnosis and treatment. Herein, HClO\u2010activatable theranostic nanoprobes, DTF\u2010FFP NPs, for image\u2010guided bacterial ablation in phagocytes are introduced. DTF\u2010FFP NPs are prepared by nanoprecipitation of an HClO\u2010responsive near\u2010infrared molecule FFP and an efficient PS DTF with aggregation\u2010induced emission characteristic using an amphiphilic polymer Pluronic F127 as the encapsulation matrix. As an energy acceptor, FFP can quench both fluorescence and production of reactive oxygen species (ROS) of DTF, thus eliminating the phototoxicity of DTF\u2010FFP NPs in normal cells and tissues. Once delivered to the infection sites, DTF\u2010FFP NPs light up with red fluorescence and efficiently generate ROS owing to the degradation of FFP by the stimulated release of HClO in phagocytes. The selective activation of fluorescence and photosensitization is successfully confirmed by both in vitro and in vivo results, demonstrating the effectiveness and theranostic potential of DTF\u2010FFP NPs in precise bacterial therapy.<\/jats:p>","DOI":"10.1002\/adma.202005222","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T11:22:07Z","timestamp":1603192927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["HClO\u2010Activated Fluorescence and Photosensitization from an AIE Nanoprobe for Image\u2010Guided Bacterial Ablation in Phagocytes"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-0107","authenticated-orcid":false,"given":"Min","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  4 Engineering Drive 4 Singapore 117585 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-217X","authenticated-orcid":false,"given":"Wenbo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  4 Engineering Drive 4 Singapore 117585 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3299-0822","authenticated-orcid":false,"given":"Yukun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  4 Engineering Drive 4 Singapore 117585 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  4 Engineering Drive 4 Singapore 117585 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital School of Medicine Zhejiang University  Hangzhou 310003 P. 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