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Due to the lack of broad\u2010spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized \u201ccapture and killing\u201d action of bacteriophages, a virus\u2010like peroxidase\u2010mimic (V\u2010POD\u2010M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal\u2013organic\u2010framework\u2010derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO<jats:sub>3<\/jats:sub>, can serve as a peroxo\u2010complex\u2010intermediate to reduce the free energy for catalyzing H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, which mainly benefits the generation of \u2022OH radicals. The unique virus\u2010like spikes endow the V\u2010POD\u2010M with fast bacterial capture and killing abilities (nearly 100% at 16 \u00b5g mL<jats:sup>\u20131<\/jats:sup>). Furthermore, the in vivo experiments show that V\u2010POD\u2010M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V\u2010POD\u2010M provides a promising broad\u2010spectrum therapy for nonantibiotic disinfection.<\/jats:p>","DOI":"10.1002\/adma.202005477","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T13:44:47Z","timestamp":1611236687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Bioinspired Spiky Peroxidase\u2010Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization"],"prefix":"10.1002","volume":"33","author":[{"given":"Ye","family":"Yang","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Department of Ultrasound West China Hospital Sichuan University  Chengdu 610065 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