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However, there is still a chronic lack of design instructions of excretable and bright AIE emitters. Here, a kind of PEGylated AIE (OTPA\u2010BBT) dots with strong absorption and extremely high second near\u2010infrared region (NIR\u2010II) PLQY of 13.6% is designed, and a long\u2010aliphatic\u2010chain design blueprint contributing to their excretion from an animal's body is proposed. Assisted by the OTPA\u2010BBT dots with bright fluorescence beyond 1100\u00a0nm and even 1500\u00a0nm (NIR\u2010IIb), large\u2010depth cerebral vasculature (beyond 600\u00a0\u00b5m) as well as real\u2010time blood flow are monitored through a thinned skull, and noninvasive NIR\u2010IIb imaging with rich high\u2010spatial\u2010frequency information gives a precise presentation of gastrointestinal tract in marmosets. Importantly, after intravenous or oral administration, the definite excretion of OTPA\u2010BBT dots from the body is demonstrated, which provides influential evidence of biosafety.<\/jats:p>","DOI":"10.1002\/adma.202008123","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T01:25:32Z","timestamp":1616203532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Biologically Excretable Aggregation\u2010Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-9616","authenticated-orcid":false,"given":"Zhe","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic Research College of Optical Science and Engineering International Research 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