{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:22:29Z","timestamp":1792264949182,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["SRG2018"],"award-info":[{"award-number":["SRG2018"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["\u2013"],"award-info":[{"award-number":["\u2013"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["00130\u2010FHS"],"award-info":[{"award-number":["00130\u2010FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Photothermal therapy (PTT), one of the most\u2010potent cancer therapeutic strategies known, is highlighted with excessive inflammatory response, while ablating cancer with immunogenic death. This hyperactive immune response may override PTT\u2010triggered immunogenicity, exacerbate skin empyrosis, and incur permanent tissue injury and high\u2010profile tumor regeneration. Therefore, an anticancer balance between pathological and protective immune response is urgently needed for an advanced photothermal therapeutic tactic. Herein, a gas\u2010modulated photothermal immunogenicity strategy is proposed by integrating an amphiphilic\u2010conjugated polymer with a polysulfide\u2010based hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) donor (2,2\u2032\u2010dipyridyl tetrasulfide@CP\u2010PEG) (where CP = conjugated polymer and PEG = poly(ethylene glycol)). The CP is endowed with NIR\u2010II fluorescence capacity and favorable photothermal effect, tracing the tumor for precise therapeutics. The polysulfide donor can release H\n                    <jats:sub>2<\/jats:sub>\n                    S triggered by intracellular glutathione, which elicits mitochondrial dysfunction and robust anti\u2010inflammation effect. Ultimately, this gas\u2010modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT\u2010induced proinflammatory tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), and interleukin\u20101beta (IL\u20101\u03b2) cytokines. Moreover, the regulated inflammation accelerates PTT\u2010induced wound healing. A H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010modulated PTT with adaptive immune response is thus recommended as an advanced strategy to cancer therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/adma.202008481","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T23:34:39Z","timestamp":1619393679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":156,"title":["Engineering a Hydrogen\u2010Sulfide\u2010Based Nanomodulator to Normalize Hyperactive Photothermal Immunogenicity for Combination Cancer Therapy"],"prefix":"10.1002","volume":"33","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisi","family":"Xie","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts and Telecommunications  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohao","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sang","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxi","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quli","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts and Telecommunications  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-7320","authenticated-orcid":false,"given":"Yunlu","family":"Dai","sequence":"additional","affiliation":[{"name":"Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau  Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.124314"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119472"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b00345"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4312"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201709648"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805936"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201906623"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202001059"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00706D"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201802290"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120314"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b06466"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14963-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2222"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7407com"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.09.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202002939"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00618K"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13193"},{"key":"e_1_2_8_13_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b01716"},{"key":"e_1_2_8_13_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119304"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909560"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adom.201900917"},{"key":"e_1_2_8_14_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15730-x"},{"key":"e_1_2_8_14_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-016-0010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705980"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00623-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021077"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.048"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201504536"},{"key":"e_1_2_8_19_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610682"},{"key":"e_1_2_8_19_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06630-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB00205B"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202008481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202008481","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202008481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:35:37Z","timestamp":1791365737000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202008481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,25]]},"references-count":36,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/adma.202008481"],"URL":"https:\/\/doi.org\/10.1002\/adma.202008481","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,25]]},"assertion":[{"value":"2020-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2008481"}}