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Here, a \u201cscaffold engineering\u201d strategy that integrates highly active single\u2010atomic iron catalysts (FeSAC) into a 3D printed bioactive glass (BG) scaffold is reported. Based on the atomically dispersed iron species within the catalysts, the engineered FeSAC displays prominent Fenton catalytic activity to generate toxic hydroxyl radicals (\u2022OH) in response to the microenvironment specific to osteosarcoma. In addition, the constructed FeSAC\u2010BG scaffold can serve as a sophisticated biomaterial platform for efficient osteosarcoma ablation, with concomitant bacterial sterilization via localized hyperthermia\u2010reinforced nanocatalytic therapeutics. The destruction of the osteosarcoma, as well as the bacterial foci, can be achieved, further preventing susceptible chronic osteomyelitis during osteogenesis. In particular, the engineered FeSAC\u2010BG scaffold is identified with advances in accelerated osteoconduction and osteoinduction, ultimately contributing to the sophisticated therapeutics and management of osteosarcoma. This work broadens the biomedical potential of single\u2010atom catalysts and offers a comprehensive clinically feasible strategy for overall osteosarcoma therapeutics, bacterial inhibition, and tissue regeneration.<\/jats:p>","DOI":"10.1002\/adma.202100150","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T10:31:18Z","timestamp":1624098678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Engineering Single\u2010Atomic Iron\u2010Catalyst\u2010Integrated 3D\u2010Printed Bioscaffolds for Osteosarcoma Destruction with Antibacterial and Bone Defect Regeneration Bioactivity"],"prefix":"10.1002","volume":"33","author":[{"given":"Liying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital Ultrasound Research and Education Institute Tongji University School of Medicine Tongji University Cancer Center Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment National Clinical Research Center of Interventional Medicine  Shanghai 200072 P. 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