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However, the physiological functions of oral and maxillofacial regions might be severely impaired and high risk of tongue tumor recurrence cannot be avoided. It is thus becoming urgently important to develop alternative strategies for tongue cancer therapy. In this regard, a new class of near\u2010infrared (NIR) light\u2010responsive and peritumoral injectable hydrogel is fabricated with extraordinary photothermal therapy (PTT) for in situ tongue tumors. The as\u2010prepared soft material exhibits good biocompatibility and ultra\u2010strong photothermal effect due to the formed network by negatively charged proteins, chitosan molecules, and Ag<jats:sub>3<\/jats:sub>AuS<jats:sub>2<\/jats:sub> nanoparticles (NPs). In a well\u2010constructed in situ tongue tumor model, tumors can be efficiently eradicated by one\u2010time PTT treatment. Importantly, there are no side effects on surrounding normal tissues and potential tumor recurrence is inhibited. 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