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However, the selection of suitable nanocarriers to deliver chloroperoxidase (CPO) and enhancement of the level of hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) in the tumor microenvironment (TME) are critical factors for improving the efficiency of EDT. In this study, a rapidly decomposing nanocomposite is designed using tetra\u2010sulfide\u2010bond\u2010incorporating dendritic mesoporous organosilica (DMOS) as a nanocarrier, followed by loading CPO and sodium\u2010hyaluronate\u2010modified calcium peroxide nanoparticles (CaO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010HA NPs). The nanocomposite can effectively generate singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) for tumor therapy without any exogenous stimulus via trimodal\u2010enhanced EDT, including DMOS\u2010induced depletion of glutathione (GSH), H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    compensation from CaO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010HA NPs in mildly acidic TME, and oxidative stress caused by overloading of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    . As tetra\u2010sulfide bonds are sensitive to GSH, DMOS can generate hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) gas as a new kind of H\n                    <jats:sub>2<\/jats:sub>\n                    S gas nanoreactor. Additionally, the overloading of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    can cause tumor calcification to accelerate in vivo tumor necrosis and promote computed tomography imaging efficacy. Therefore, a novel H\n                    <jats:sub>2<\/jats:sub>\n                    S gas, EDT, and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010interference combined therapy strategy is developed.\n                  <\/jats:p>","DOI":"10.1002\/adma.202101223","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T01:05:52Z","timestamp":1623978352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":151,"title":["A Tumor\u2010Microenvironment\u2010Responsive Nanocomposite for Hydrogen Sulfide Gas and Trimodal\u2010Enhanced Enzyme Dynamic Therapy"],"prefix":"10.1002","volume":"33","author":[{"given":"Bin","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. 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